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    Method for measuring absolute value of thermal conductivity
    2.
    发明授权
    Method for measuring absolute value of thermal conductivity 有权
    热导率绝对值测定方法

    公开(公告)号：US06497509B2

    公开(公告)日：2002-12-24

    申请号：US09877390

    申请日：2001-06-08

    Applicant: Mikhail Merzliakov ,  Christoph Schick

    Inventor： Mikhail Merzliakov ,  Christoph Schick

    IPC: G01N2520

    CPC classification number: G01N25/18 ,  G01N25/005 ,  G01N25/4833 ,  G01N25/4866

    Abstract: A method of measuring the absolute value of thermal conductivity of low thermal conducting solid materials is disclosed. Thermal conductivity and heat capacity of the sample are determined simultaneously in a single measurement with the prerequisite that these values are frequency independent. This method is realized on power-compensated differential scanning calorimeters without any modification in the measuring system. DSC is calibrated in a standard way for temperature and heat flow. The method uses temperature-time profiles consisting of one fast temperature jump of 0.5 to 2 K and an isotherm. The measuring time for each temperature is less than 1 min. As input parameters only sample thickness and contact area with the DSC furnace (or sample diameter if the sample is disk shaped) are needed together with sample mass. In addition to the sample thermal conductivity and heat capacity the effective thermal contact between sample and DSC furnace is determined.

    Abstract translation: 公开了一种测量低导热固体材料的导热绝对值的方法。 在单次测量中同时测定样品的热导率和热容量，前提是这些值是频率无关的。 该方法在功率补偿差示扫描量热仪上实现，在测量系统中无任何变化。 DSC以标准方式校准温度和热流量。 该方法使用由0.5〜2K的一次快速温度跳变和等温线组成的温度 - 时间曲线。 每个温度的测量时间小于1分钟。 由于输入参数与样品质量一起需要与DSC炉的样品厚度和接触面积（或样品是盘形的样品直径）。 除了样品的热导率和热容量之外，确定样品和DSC炉之间的有效热接触。

    Novel Gold-Based Nanocrystals for Medical Treatments and Electrochemical Manufacturing Processes Therefor
    6.
    发明申请
    Novel Gold-Based Nanocrystals for Medical Treatments and Electrochemical Manufacturing Processes Therefor 有权
    用于医疗治疗和电化学制造工艺的新型金基纳米晶体

    公开(公告)号：US20130259903A1

    公开(公告)日：2013-10-03

    申请号：US13382781

    申请日：2010-07-08

    Applicant: Mark Gordon Mortenson ,  D. Kyle Pierce ,  David A. Bryce ,  Adam R. Dorfman ,  Reed N. Wilcox ,  Anthony Lockett ,  Mikhail Merzliakov

    Inventor： Mark Gordon Mortenson ,  D. Kyle Pierce ,  David A. Bryce ,  Adam R. Dorfman ,  Reed N. Wilcox ,  Anthony Lockett ,  Mikhail Merzliakov

    IPC: A61K33/24 ,  A61K9/08

    CPC classification number: A61K33/24 ,  A61K9/0095 ,  A61K9/08 ,  A61K9/10 ,  A61K9/14 ,  A61K47/02 ,  B22F1/0022 ,  B22F9/00 ,  B22F2001/0037 ,  B82Y30/00 ,  C30B7/12 ,  C30B29/02 ,  C30B29/60 ,  Y02A50/401 ,  Y02A50/411

    Abstract: The present invention relates to novel gold nanocrystals and nanocrystal shape distributions that have surfaces that are substantially free from organic impurities or films. Specifically, the surfaces are “clean” relative to the surfaces of gold nanoparticles made using chemical reduction processes that require organic reductants and/or surfactants to grow gold nanoparticles from gold ions in solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the gold-based nanocrystals. The invention further includes pharmaceutical compositions thereof and the use of the gold nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which gold therapy is already known and more generally for conditions resulting from pathological cellular activation, such as inflammatory (including chronic inflammatory) conditions, autoimmune conditions, hypersensitivity reactions and/or cancerous diseases or conditions In one embodiment, the condition is mediated by MIF (macrophage migration inhibiting factor).

    Abstract translation: 本发明涉及具有基本上不含有机杂质或膜的表面的新的金纳米晶体和纳米晶体形状分布。 具体地说，相对于使用需要有机还原剂和/或表面活性剂的化学还原方法制备的金纳米颗粒的表面，表面是“干净的”，以从溶液中的金离子生长金纳米颗粒。 本发明包括用于制造金基纳米晶体的新型电化学制造装置和技术。 本发明还包括其药物组合物和金纳米晶体或其悬浮液或胶体用于治疗或预防已知金疗法的疾病或病症，更一般地，用于由病理性细胞活化引起的病症，例如炎性（ 包括慢性炎症）病症，自身免疫病症，超敏反应和/或癌性疾病或病症在一个实施方案中，该病症由MIF（巨噬细胞迁移抑制因子）介导。

    Novel Gold-Platinum Based Bi-Metallic Nanocrystal Suspensions, Electrochemical Manufacturing Processes Therefor and Uses for the Same
    8.
    发明申请
    Novel Gold-Platinum Based Bi-Metallic Nanocrystal Suspensions, Electrochemical Manufacturing Processes Therefor and Uses for the Same 审中-公开
    新型金 - 铂基双金属纳米晶体悬浮液，其电化学制造工艺及其用途

    公开(公告)号：US20160317578A1

    公开(公告)日：2016-11-03

    申请号：US15204534

    申请日：2016-07-07

    Applicant: Adam R. Dorfman ,  David A. Bryce ,  Maxwell A. Grace ,  D. Kyle Pierce ,  Mikhail Merzliakov ,  Mark G. Mortenson

    Inventor： Adam R. Dorfman ,  David A. Bryce ,  Maxwell A. Grace ,  D. Kyle Pierce ,  Mikhail Merzliakov ,  Mark G. Mortenson

    IPC: A61K33/24 ,  A61K9/16

    CPC classification number: A61K33/24 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1611 ,  B82Y5/00 ,  C22C1/0466 ,  C22C5/02 ,  C22C5/04 ,  C22C30/00

    Abstract: The present invention relates to novel gold-platinum based bi-metallic nanocrystal suspensions that have nanocrystal surfaces that are substantially free from organic or other impurities or films associated with typical chemical reductants/stabilizers and/or raw materials used in nanoparticle formation processes. Specifically, the surfaces are “clean” relative to the surfaces of metal-based nanoparticles made using chemical reduction (and other) processes that require organic (or other) reductants and/or surfactants to grow (and/or suspend) metal nanoparticles from metal ions in a solution.The invention includes novel electrochemical manufacturing apparatuses and techniques for making the bi-metallic nanocrystal suspensions. The techniques do not require the use or presence of chlorine ions/atoms and/or chlorides or chlorine-based materials for the manufacturing process/final suspension. The invention further includes pharmaceutical compositions thereof and the use of the bi-metallic nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which metal-based therapy is already known, including, for example, for cancerous diseases or conditions.

    Abstract translation: 本发明包括用于制备双金属纳米晶体悬浮液的新型电化学制造装置和技术。 这些技术不需要使用或存在氯离子/原子和/或氯化物或氯基材料用于制造过程/最终悬浮液。 本发明还包括其药物组合物，以及双金属纳米晶体或其悬浮液或胶体在治疗或预防金属基治疗已知的疾病或病症中的应用，包括例如癌性疾病或病症 。

    CONTINUOUS, SEMICONTINUOUS AND BATCH METHODS FOR TREATING LIQUIDS AND MANUFACTURING CERTAIN CONSTITUENTS (E.G.,NANOPARTICLES) IN LIQUIDS, APPARATUSES AND NANOPARTICLES AND NANOPARTICLE/LIQUID SOLUTION(S) AND COLLOIDS RESULTING THEREFROM
    9.
    发明申请
    CONTINUOUS, SEMICONTINUOUS AND BATCH METHODS FOR TREATING LIQUIDS AND MANUFACTURING CERTAIN CONSTITUENTS (E.G.,NANOPARTICLES) IN LIQUIDS, APPARATUSES AND NANOPARTICLES AND NANOPARTICLE/LIQUID SOLUTION(S) AND COLLOIDS RESULTING THEREFROM 审中-公开
    连续的，用于处理液体和制造液体，装置和纳米颗粒中的某些组分（E.G.，NANOPARTICLES）和纳米颗粒的液体溶液和液体溶液的半成品和批量方法

    公开(公告)号：US20150167189A1

    公开(公告)日：2015-06-18

    申请号：US14338868

    申请日：2014-08-25

    Applicant: David Kyle Pierce ,  Mark Gordon Mortenson ,  David Andrew Bryce ,  Adam Robert Dorfman ,  Mikhail Merzliakov ,  Arthur Maxwell Grace

    Inventor： David Kyle Pierce ,  Mark Gordon Mortenson ,  David Andrew Bryce ,  Adam Robert Dorfman ,  Mikhail Merzliakov ,  Arthur Maxwell Grace

    IPC: C25C1/22

    CPC classification number: B22F9/20 ,  B01J19/088 ,  B01J2219/0809 ,  B01J2219/0841 ,  B01J2219/0877 ,  B01J2219/0894 ,  B22F2999/00 ,  B82Y40/00 ,  C25C1/20 ,  C25C1/22 ,  B22F2202/06 ,  B22F2202/13

    Abstract: This invention relates generally to novel methods and novel devices for the continuous manufacture of nanoparticles, microparticles and nanoparticle/liquid solution(s) (e.g., colloids). The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e.g., nanoparticles) are caused to be present (e.g., created and/or the liquid is predisposed to their presence (e.g., conditioned)) in a liquid (e.g., water) by, for example, preferably utilizing at least one adjustable plasma (e.g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. At least one subsequent and/or substantially simultaneous adjustable electrochemical processing technique is also preferred. Multiple adjustable plasmas and/or adjustable electrochemical processing techniques are preferred. Processing enhancers can be utilized alone or with a plasma. Semicontinuous and batch processes can also be utilized. The continuous processes cause at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s). Results include constituents formed in the liquid including ions, micron-sized particles and/or nanoparticles (e.g., metallic-based nanoparticles) of novel size, shape, composition, concentration, zeta potential and certain other novel properties present in a liquid.

    Abstract translation: 本发明一般涉及用于连续制造纳米颗粒，微粒和纳米颗粒/液体溶液（例如胶体）的新方法和新颖装置。 纳米颗粒（和/或微米尺寸的颗粒）包含各种可能的组合物，尺寸和形状。 引起颗粒（例如，纳米颗粒）存在（例如，通过例如优选利用至少一种的方式在液体（例如水）中存在（例如，产生和/或将液体倾向于其存在（例如，调节）） 可调节的等离子体（例如，由至少一个AC和/或DC电源产生），其等离子体与液体的至少一部分表面连通。 至少一个后续和/或基本上同时可调节的电化学处理技术也是优选的。 多重可调等离子体和/或可调电化学处理技术是优选的。 处理增强剂可以单独使用或与等离子体一起使用。 也可以使用半连续和间歇方法。 连续过程导致至少一种液体流入，通过和流出至少一个槽构件，这种液体在所述槽构件中被处理，调节和/或实现。 结果包括在液体中形成的成分，包括具有新颖尺寸，形状，组成，浓度，ζ电位和存在于液体中的某些其它新特性的离子，微米级颗粒和/或纳米颗粒（例如金属基纳米颗粒）。

    Continuous, Semicontinuous and Batch Methods for Treating Liquids and Manufacturing Certain Constituents (e.g., Nanoparticles) in Liquids, Apparatuses and Nanoparticles and Nanoparticle/Liquid Solution(s) and Colloids Resulting Therefrom
    10.
    发明申请
    Continuous, Semicontinuous and Batch Methods for Treating Liquids and Manufacturing Certain Constituents (e.g., Nanoparticles) in Liquids, Apparatuses and Nanoparticles and Nanoparticle/Liquid Solution(s) and Colloids Resulting Therefrom 有权
    用于处理液体并在液体，装置和纳米颗粒中制备某些成分（例如纳米颗粒）和纳米颗粒/液体溶液的连续，半连续和分批方法以及由此产生的胶体

    公开(公告)号：US20110278178A1

    公开(公告)日：2011-11-17

    申请号：US13144221

    申请日：2010-01-13

    Applicant: David Kyle Pierce ,  Mark Gordon Mortenson ,  David Andrew Bryce ,  Adam Robert Dorfman ,  Mikhail Merzliakov ,  Arthur Maxwell Grace

    Inventor： David Kyle Pierce ,  Mark Gordon Mortenson ,  David Andrew Bryce ,  Adam Robert Dorfman ,  Mikhail Merzliakov ,  Arthur Maxwell Grace

    IPC: C25C7/02 ,  C25C1/16 ,  C25C7/06 ,  C25C1/22

    CPC classification number: B22F9/20 ,  B01J19/088 ,  B01J2219/0809 ,  B01J2219/0841 ,  B01J2219/0877 ,  B01J2219/0894 ,  B22F2999/00 ,  B82Y40/00 ,  C25C1/20 ,  C25C1/22 ,  B22F2202/06 ,  B22F2202/13

    Abstract: This invention relates generally to novel methods and novel devices for the continuous manufacture of nanoparticles, microparticles and nanoparticle/liquid solution(s) (e.g., colloids). The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e.g., nanoparticles) are caused to be present (e.g., created and/or the liquid is predisposed to their presence (e.g., conditioned)) in a liquid (e.g., water) by, for example, preferably utilizing at least one adjustable plasma (e.g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. At least one subsequent and/or substantially simultaneous adjustable electrochemical processing technique is also preferred. Multiple adjustable plasmas and/or adjustable electrochemical processing techniques are preferred. Processing enhancers can be utilized alone or with a plasma. Semicontinuous and batch processes can also be utilized. The continuous processes cause at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s). Results include constituents formed in the liquid including ions, micron-sized particles and/or nanoparticles (e.g., metallic-based nanoparticles) of novel size, shape, composition, concentration, zeta potential and certain other novel properties present in a liquid.

    Abstract translation: 本发明一般涉及用于连续制造纳米颗粒，微粒和纳米颗粒/液体溶液（例如胶体）的新方法和新颖装置。 纳米颗粒（和/或微米尺寸的颗粒）包含各种可能的组合物，尺寸和形状。 引起颗粒（例如，纳米颗粒）存在（例如，通过例如优选利用至少一种的方式在液体（例如水）中存在（例如，产生和/或将液体倾向于其存在（例如，调节）） 可调节的等离子体（例如，由至少一个AC和/或DC电源产生），其等离子体与液体的至少一部分表面连通。 至少一个后续和/或基本上同时可调节的电化学处理技术也是优选的。 多重可调等离子体和/或可调电化学处理技术是优选的。 处理增强剂可以单独使用或与等离子体一起使用。 也可以使用半连续和间歇方法。 连续过程导致至少一种液体流入，通过和流出至少一个槽构件，这种液体在所述槽构件中被处理，调节和/或实现。 结果包括在液体中形成的成分，包括具有新颖尺寸，形状，组成，浓度，ζ电位和存在于液体中的某些其它新特性的离子，微米级颗粒和/或纳米颗粒（例如金属基纳米颗粒）。

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