Systems, apparatus, and methods to workload optimize hardware are disclosed herein. An example apparatus includes power control circuitry to determine an application ratio based on an instruction to be executed by one or more cores of a processor to execute a workload, and configure, before the execution of the workload, at least one of (i) the one or more cores of the processor based on the application ratio or (ii) uncore logic of the processor based on the application ratio, and execution circuitry to execute the workload with the at least one of the one or more cores or the uncore logic.