The present technology provides nanoparticles comprising an inorganic core and NAD+ or NADH, coated with a lipid bilayer, wherein the inorganic core is selected from calcium phosphate or a metal organic framework (MOF); the MOF comprises a transition metal ion coordinated to a coordinating ligand, wherein the transition metal ion is selected from the group consisting of zinc, iron, zirconium, copper, and cobalt ions, and the coordinating ligand is selected from an imidazolate ligand or a carboxylate ligand; and the nanoparticle has an average hydrodynamic diameter of from at least 50 nm to less than 1000 nm. Pharmaceutical compositions incorporating such nanoparticles and methods of treating sepsis and/or inflammation with such particles are also provided.