公开(公告)号：US20230032473A1

公开(公告)日：2023-02-02

申请号：US17741298

申请日：2022-05-10

Applicant: Wisconsin Alumni Research Foundation

Inventor： Shaoqin Gong ,  Mingzhou Ye ,  Yi Zhao

IPC: A61K31/7084 ,  A61K9/127 ,  A61K47/02 ,  A61K47/22 ,  A61K31/496 ,  A61K31/192 ,  A61K31/65 ,  A61K31/7052 ,  A61K31/7036 ,  A61K31/513 ,  A61K31/522 ,  A61K31/4174 ,  A61K31/4196 ,  A61K31/506 ,  A61P31/04

Abstract: The present technology provides nanoparticles comprising an inorganic core and NAD+ or NADH, coated with a lipid bilayer, wherein the inorganic core is selected from calcium phosphate or a metal organic framework (MOF); the MOF comprises a transition metal ion coordinated to a coordinating ligand, wherein the transition metal ion is selected from the group consisting of zinc, iron, zirconium, copper, and cobalt ions, and the coordinating ligand is selected from an imidazolate ligand or a carboxylate ligand; and the nanoparticle has an average hydrodynamic diameter of from at least 50 nm to less than 1000 nm. Pharmaceutical compositions incorporating such nanoparticles and methods of treating sepsis and/or inflammation with such particles are also provided.

公开(公告)号：US20240335392A1

公开(公告)日：2024-10-10

申请号：US18580703

申请日：2022-07-21

Applicant: University of Virginia Patent Foundation ,  WISCONSIN ALUMNI RESEARCH FOUNDATION

Inventor： Kenneth Craig Kent ,  Liang-Wang Guo ,  Bowen Wang ,  Takuro Shirasu ,  Shaoqin Gong ,  Yi Zhao

IPC: A61K9/51 ,  A61K31/517 ,  A61P9/14

CPC classification number: A61K9/5176 ,  A61K9/5146 ,  A61K31/517 ,  A61P9/14

Abstract: In one aspect, the disclosure relates to nanoclusters comprising cores comprising self-assembled unimolecular nanoparticles and biomimetic membrane coatings surrounding the cores, methods of making the same, and methods of treating and preventing restenosis using same. In some embodiments, the nanoclusters can contain an anti-restenotic drug. In one embodiment, the polymers and/or copolymers of the unimolecular nanoparticles can contain a hydrophobic group such as, for example, a phenylboronic ester. In a further embodiment, the biomimetic membrane can localize the nanoclusters at sites of vascular damage, at which time reactive oxygen species (ROS) at the sites of vascular damage cleave the hydrophobic groups from the polymers and/or copolymers, increasing hydrophilicity of the polymers and/or copolymers and allowing for greater tissue penetration of the de-clustered nanoclusters and nanoparticles.