- 专利标题: CLEAVABLE CYCLIC LOOP NUCLEOTIDES FOR NANOPORE SEQUENCING
-
申请号: US18311876申请日: 2023-05-03
-
公开(公告)号: US20230357307A1公开(公告)日: 2023-11-09
- 发明人: Abdul Sadeer Abd Salam , Xiangyuan Yang , Hassan Zakiruddin Bohra , Yin Nah Teo , Min Yen Lee , Ramesh Neelakandan , Jeffrey G. Mandell , Erin Garcia , Sharyuen Soh , Daniel Hartoyo Lukamto
- 申请人: ILLUMINA, INC. , ILLUMINA SINGAPORE PTE LTD.
- 申请人地址: US CA San Diego
- 专利权人: ILLUMINA, INC.,ILLUMINA SINGAPORE PTE LTD.
- 当前专利权人: ILLUMINA, INC.,ILLUMINA SINGAPORE PTE LTD.
- 当前专利权人地址: US CA San Diego
- 主分类号: C07H21/00
- IPC分类号: C07H21/00 ; C12Q1/6869 ; C07H19/10
摘要:
In one aspect, the disclosed technology relates to nanopore sequencing with a polynucleotide comprising a plurality of nucleotides, wherein each nucleotide comprises a linker construct between two positions of the nucleotide, wherein the linker construct optionally comprises a reporter moiety corresponding to the identity of the nucleotide, and wherein the linker construct is a part of the cleavable cyclic loop nucleotide comprising a cleavable site. In some embodiments, the nucleotides further comprise arresting constructs for slowing or halting the polynucleotide translocation through a nanopore.
信息查询