- 专利标题: BICYCLOHEPTANE PYRROLIDINE OREXIN RECEPTOR AGONISTS
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申请号: US18040896申请日: 2021-08-16
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公开(公告)号: US20230365533A1公开(公告)日: 2023-11-16
- 发明人: Stephane L. Bogen , Dane James Clausen , Deodial Guy Guiadeen , Jinsong Hao , Shishi Lin , Michael T. Rudd , Lan Wei , Li Xiao , Dexi Yang
- 申请人: Stephane L. BOGEN , Dane James CLAUSEN , Deodial Guy GUIADEEN , Jinsong HAO , Shishi LIN , Michael T. RUDD , Lan WEI , Li XIAO , Dexi YANG , MERCK SHARP & DOHME CORP.
- 申请人地址: US NJ Kenilworth
- 专利权人: Merck Sharp & Dohme LLC
- 当前专利权人: Merck Sharp & Dohme LLC
- 当前专利权人地址: US NJ Rahway
- 国际申请: PCT/US2021/046098 2021.08.16
- 进入国家日期: 2023-02-07
- 主分类号: C07D403/12
- IPC分类号: C07D403/12 ; C07D403/14 ; C07D417/12 ; C07D491/048
摘要:
The present invention is directed to bicyclo[4.1 0]heptane pyrrolidine compounds of formula (I) which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
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