公开(公告)号：US20230365533A1

公开(公告)日：2023-11-16

申请号：US18040896

申请日：2021-08-16

Applicant: Stephane L. BOGEN ,  Dane James CLAUSEN ,  Deodial Guy GUIADEEN ,  Jinsong HAO ,  Shishi LIN ,  Michael T. RUDD ,  Lan WEI ,  Li XIAO ,  Dexi YANG ,  MERCK SHARP & DOHME CORP.

Inventor： Stephane L. Bogen ,  Dane James Clausen ,  Deodial Guy Guiadeen ,  Jinsong Hao ,  Shishi Lin ,  Michael T. Rudd ,  Lan Wei ,  Li Xiao ,  Dexi Yang

IPC: C07D403/12 ,  C07D403/14 ,  C07D417/12 ,  C07D491/048

CPC classification number: C07D403/12 ,  C07D403/14 ,  C07D417/12 ,  C07D491/048

Abstract: The present invention is directed to bicyclo[4.1 0]heptane pyrrolidine compounds of formula (I) which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.




where




is




wherein n is 0 or 1;

公开(公告)号：US20220089585A1

公开(公告)日：2022-03-24

申请号：US17422642

申请日：2020-01-10

Applicant: Dane James CLAUSEN ,  Joseph A. KOZLOWSKI ,  Jian LIU ,  Scott E. WOLKENBERG ,  Wensheng YU ,  Merck Sharp & Dohme Corp.

Inventor： Dane James Clausen ,  Joseph A. Kozlowski ,  Jian Liu ,  Scott E. Wolkenberg ,  Wengsheng Yu

IPC: C07D413/14 ,  C07D413/12 ,  A61K45/06 ,  A61K31/422 ,  A61K31/4709 ,  C07D417/14 ,  A61P31/18

Abstract: The present invention relates to Compounds of Formula I and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, R4, X and A are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treating or preventing HIV infection in a subject.