公开(公告)号：US20230365533A1

公开(公告)日：2023-11-16

申请号：US18040896

申请日：2021-08-16

申请人： Stephane L. BOGEN ,  Dane James CLAUSEN ,  Deodial Guy GUIADEEN ,  Jinsong HAO ,  Shishi LIN ,  Michael T. RUDD ,  Lan WEI ,  Li XIAO ,  Dexi YANG ,  MERCK SHARP & DOHME CORP.

发明人： Stephane L. Bogen ,  Dane James Clausen ,  Deodial Guy Guiadeen ,  Jinsong Hao ,  Shishi Lin ,  Michael T. Rudd ,  Lan Wei ,  Li Xiao ,  Dexi Yang

IPC分类号： C07D403/12 ,  C07D403/14 ,  C07D417/12 ,  C07D491/048

CPC分类号： C07D403/12 ,  C07D403/14 ,  C07D417/12 ,  C07D491/048

摘要： The present invention is directed to bicyclo[4.1 0]heptane pyrrolidine compounds of formula (I) which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.




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