公开(公告)号：US20180009828A1

公开(公告)日：2018-01-11

申请号：US15538957

申请日：2015-12-17

申请人： JIAN LIU ,  JOSEPH A. KOZLOWSKI ,  XIAOLEI GAO ,  DEODIAL GUY GUIADEEN ,  SHILAN LIU ,  DAHAI WANG

发明人： JIAN LIU ,  JOSEPH A. KOZLOWSKI ,  XIAOLEI GAO ,  DEODIAL GUY GUIADEEN ,  SHILAN LIU ,  DAHAI WANG

IPC分类号： C07D519/00 ,  A61K31/4985

CPC分类号： C07D519/00 ,  A61K31/4985 ,  A61K45/06

摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, Formula (I) or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.

公开(公告)号：US20170342076A1

公开(公告)日：2017-11-30

申请号：US15538910

申请日：2015-12-17

申请人： JIAN LIU ,  JOSEPH A. KOZLOWSKI ,  BRIAN M. ANDRESEN ,  SOBHANA BABU BOGA ,  XIAOLEI GAO ,  DEODIAL GUY GUIADEEN ,  JIAQIANG CAI ,  SHILAN LIU ,  DAHAI WANG ,  HAO WU ,  CHUNDAO YANG

发明人： JIAN LIU ,  JOSEPH A. KOZLOWSKI ,  BRIAN M. ANDRESEN ,  SOBHANA BABU BOGA ,  XIAOLEI GAO ,  DEODIAL GUY GUIADEEN ,  JIAQIANG CAI ,  SHILAN LIU ,  DAHAI WANG ,  HAO WU ,  CHUNDAO YANG

IPC分类号： C07D487/04 ,  A61K31/4985

CPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K45/06

摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I, or pharmaceutically acceptable salts thereof, Formula I or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.

公开(公告)号：US20230365533A1

公开(公告)日：2023-11-16

申请号：US18040896

申请日：2021-08-16

申请人： Stephane L. BOGEN ,  Dane James CLAUSEN ,  Deodial Guy GUIADEEN ,  Jinsong HAO ,  Shishi LIN ,  Michael T. RUDD ,  Lan WEI ,  Li XIAO ,  Dexi YANG ,  MERCK SHARP & DOHME CORP.

发明人： Stephane L. Bogen ,  Dane James Clausen ,  Deodial Guy Guiadeen ,  Jinsong Hao ,  Shishi Lin ,  Michael T. Rudd ,  Lan Wei ,  Li Xiao ,  Dexi Yang

IPC分类号： C07D403/12 ,  C07D403/14 ,  C07D417/12 ,  C07D491/048

CPC分类号： C07D403/12 ,  C07D403/14 ,  C07D417/12 ,  C07D491/048

摘要： The present invention is directed to bicyclo[4.1 0]heptane pyrrolidine compounds of formula (I) which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.




where




is




wherein n is 0 or 1;

公开(公告)号：US20170362243A1

公开(公告)日：2017-12-21

申请号：US15538925

申请日：2015-12-17

申请人： JIAN LIU ,  JOSEPH A. KOZLOWSKI ,  SOBHANA BABU BOGA ,  XIAOLEI GAO ,  DEODIAL GUY GUIADEEN ,  JYHSHING WANG ,  SHILAN LIU

发明人： JIAN LIU ,  JOSEPH A. KOZLOWSKI ,  SOBHANA BABU BOGA ,  XIAOLEI GAO ,  DEODIAL GUY GUIADEEN ,  JYHSHING WANG ,  SHILAN LIU

IPC分类号： C07D487/04 ,  A61K31/4985

CPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K45/06 ,  A61P3/10 ,  A61P11/00 ,  A61P11/06 ,  A61P19/02 ,  A61P29/00 ,  A61P37/00 ,  A61P37/06

摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.

公开(公告)号：US20230227441A1

公开(公告)日：2023-07-20

申请号：US18009306

申请日：2021-06-14

申请人： Ashok ARASAPPAN ,  Ian M. BELL ,  Christopher James BUNGARD ,  Christopher S. BURGEY ,  Jason M. COX ,  Deodial Guy GUIADEEN ,  Michael J. KELLY ,  Mark E. LAYTON ,  Hong LIU ,  Jian LIU ,  James T. OLSEN ,  James J. PERKINS ,  Jeffrey W. SCHUBERT ,  Akshay A. SHAH ,  Michael D. VANHEYST ,  Zhe WU ,  Shawn J. STACHEL ,  MERCK SHARP & DOHME CORP.

发明人： Ashok Arasappan ,  Ian M. Bell ,  Christopher James Bungard ,  Christopher S. Burgey ,  Jason Michael Cox ,  Deodial Guy Guiadeen, III ,  Michael J. Kelly, III ,  Mark E. Layton ,  Hong Liu ,  Jian Liu ,  James T. Olsen ,  James J. Perkins ,  Jeffrey W. Schubert ,  Akshay A. Shah ,  Shawn J. Stachel ,  Michael David VanHeyst ,  Zhe Wu

IPC分类号： C07D413/12 ,  C07D263/24 ,  C07D417/12

CPC分类号： C07D413/12 ,  C07D263/24 ,  C07D417/12

摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

公开(公告)号：US10208047B2

公开(公告)日：2019-02-19

申请号：US15538910

申请日：2015-12-17

申请人： Jian Liu ,  Joseph A. Kozlowski ,  Brian M. Andresen ,  Sobhana Babu Boga ,  Xiaolei Gao ,  Deodial Guy Guiadeen ,  Jiaqiang Cai ,  Shilan Liu ,  Dahai Wang ,  Hao Wu ,  Chundao Yang

发明人： Jian Liu ,  Joseph A. Kozlowski ,  Brian M. Andresen ,  Sobhana Babu Boga ,  Xiaolei Gao ,  Deodial Guy Guiadeen ,  Jiaqiang Cai ,  Shilan Liu ,  Dahai Wang ,  Hao Wu ,  Chundao Yang

IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K45/06

摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I, or pharmaceutically acceptable salts thereof, Formula I or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.

公开(公告)号：US20180079752A1

公开(公告)日：2018-03-22

申请号：US15578775

申请日：2016-05-31

申请人： ADRIANUS PETRUS ANTONIUS DE MAN ,  RONALD KIM ,  JIAN LIU ,  JOSEPH A. KOZLOWSKI ,  SOBHANA BABU BOGA ,  THIERRY FISCHMANN ,  DEODIAL Guy GUIADEEN ,  ILSE HENDRICA MARIA POLS-DE ROOIJ ,  SHILAN LIU ,  HAO WU

发明人： ADRIANUS PETRUS ANTONIUS DE MAN ,  RONALD KIM ,  JIAN LIU ,  JOSEPH A. KOZLOWSKI ,  SOBHANA BABU BOGA ,  THIERRY FISCHMANN ,  DEODIAL Guy GUIADEEN ,  ILSE HENDRICA MARIA POLS-DE ROOIJ ,  SHILAN LIU ,  HAO WU

IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/5377

CPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/5377 ,  A61P19/02

摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.

公开(公告)号：US20170362242A1

公开(公告)日：2017-12-21

申请号：US15538902

申请日：2015-12-17

申请人： JIAN LIU ,  JOSEPH A. KOZLOWSKI ,  ABDUL-BASIT ALHASSAN ,  SOBHANA BABU BOGA ,  XIAOLEI GAO ,  DEODIAL GUY GUIADEEN ,  JYHSHING WANG ,  WENSHENG YU ,  JIAQIANG CAI ,  SHILAN LIU ,  DAHAI WANG ,  HAO WU ,  CHUNDAO YANG

发明人： JIAN LIU ,  JOSEPH A. KOZLOWSKI ,  ABDUL-BASIT ALHASSAN ,  SOBHANA BABU BOGA ,  XIAOLEI GAO ,  DEODIAL GUY GUIADEEN ,  JYHSHING WANG ,  WENSHENG YU ,  JIAQIANG CAI ,  SHILAN LIU ,  DAHAI WANG ,  HAO WU ,  CHUNDAO YANG

IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/5377 ,  C07D519/00

CPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/5377 ,  A61K45/06 ,  A61P37/02 ,  C07D519/00

摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.