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公开(公告)号：US20180009828A1
公开(公告)日：2018-01-11
申请号：US15538957
申请日：2015-12-17
Applicant: JIAN LIU , JOSEPH A. KOZLOWSKI , XIAOLEI GAO , DEODIAL GUY GUIADEEN , SHILAN LIU , DAHAI WANG
Inventor： JIAN LIU , JOSEPH A. KOZLOWSKI , XIAOLEI GAO , DEODIAL GUY GUIADEEN , SHILAN LIU , DAHAI WANG
IPC: C07D519/00 , A61K31/4985
CPC classification number: C07D519/00 , A61K31/4985 , A61K45/06
Abstract: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, Formula (I) or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.
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公开(公告)号：US20170342076A1
公开(公告)日：2017-11-30
申请号：US15538910
申请日：2015-12-17
Applicant: JIAN LIU , JOSEPH A. KOZLOWSKI , BRIAN M. ANDRESEN , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JIAQIANG CAI , SHILAN LIU , DAHAI WANG , HAO WU , CHUNDAO YANG
Inventor： JIAN LIU , JOSEPH A. KOZLOWSKI , BRIAN M. ANDRESEN , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JIAQIANG CAI , SHILAN LIU , DAHAI WANG , HAO WU , CHUNDAO YANG
IPC: C07D487/04 , A61K31/4985
CPC classification number: C07D487/04 , A61K31/4985 , A61K45/06
Abstract: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I, or pharmaceutically acceptable salts thereof, Formula I or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.
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公开(公告)号：US20230365533A1
公开(公告)日：2023-11-16
申请号：US18040896
申请日：2021-08-16
Applicant: Stephane L. BOGEN , Dane James CLAUSEN , Deodial Guy GUIADEEN , Jinsong HAO , Shishi LIN , Michael T. RUDD , Lan WEI , Li XIAO , Dexi YANG , MERCK SHARP & DOHME CORP.
Inventor： Stephane L. Bogen , Dane James Clausen , Deodial Guy Guiadeen , Jinsong Hao , Shishi Lin , Michael T. Rudd , Lan Wei , Li Xiao , Dexi Yang
IPC: C07D403/12 , C07D403/14 , C07D417/12 , C07D491/048
CPC classification number: C07D403/12 , C07D403/14 , C07D417/12 , C07D491/048
Abstract: The present invention is directed to bicyclo[4.1 0]heptane pyrrolidine compounds of formula (I) which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
where
is
wherein n is 0 or 1;-
Patent Agency Ranking
公开(公告)号：US20170362243A1
公开(公告)日：2017-12-21
申请号：US15538925
申请日：2015-12-17
Applicant: JIAN LIU , JOSEPH A. KOZLOWSKI , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JYHSHING WANG , SHILAN LIU
Inventor： JIAN LIU , JOSEPH A. KOZLOWSKI , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JYHSHING WANG , SHILAN LIU
IPC: C07D487/04 , A61K31/4985
CPC classification number: C07D487/04 , A61K31/4985 , A61K45/06 , A61P3/10 , A61P11/00 , A61P11/06 , A61P19/02 , A61P29/00 , A61P37/00 , A61P37/06
Abstract: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
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公开(公告)号：US20230227441A1
公开(公告)日：2023-07-20
申请号：US18009306
申请日：2021-06-14
Applicant: Ashok ARASAPPAN , Ian M. BELL , Christopher James BUNGARD , Christopher S. BURGEY , Jason M. COX , Deodial Guy GUIADEEN , Michael J. KELLY , Mark E. LAYTON , Hong LIU , Jian LIU , James T. OLSEN , James J. PERKINS , Jeffrey W. SCHUBERT , Akshay A. SHAH , Michael D. VANHEYST , Zhe WU , Shawn J. STACHEL , MERCK SHARP & DOHME CORP.
Inventor： Ashok Arasappan , Ian M. Bell , Christopher James Bungard , Christopher S. Burgey , Jason Michael Cox , Deodial Guy Guiadeen, III , Michael J. Kelly, III , Mark E. Layton , Hong Liu , Jian Liu , James T. Olsen , James J. Perkins , Jeffrey W. Schubert , Akshay A. Shah , Shawn J. Stachel , Michael David VanHeyst , Zhe Wu
IPC: C07D413/12 , C07D263/24 , C07D417/12
CPC classification number: C07D413/12 , C07D263/24 , C07D417/12
Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.
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公开(公告)号：US10208047B2
公开(公告)日：2019-02-19
申请号：US15538910
申请日：2015-12-17
Applicant: Jian Liu , Joseph A. Kozlowski , Brian M. Andresen , Sobhana Babu Boga , Xiaolei Gao , Deodial Guy Guiadeen , Jiaqiang Cai , Shilan Liu , Dahai Wang , Hao Wu , Chundao Yang
Inventor： Jian Liu , Joseph A. Kozlowski , Brian M. Andresen , Sobhana Babu Boga , Xiaolei Gao , Deodial Guy Guiadeen , Jiaqiang Cai , Shilan Liu , Dahai Wang , Hao Wu , Chundao Yang
IPC: C07D487/04 , A61K31/4985 , A61K45/06
Abstract: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I, or pharmaceutically acceptable salts thereof, Formula I or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.
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公开(公告)号：US20180079752A1
公开(公告)日：2018-03-22
申请号：US15578775
申请日：2016-05-31
Applicant: ADRIANUS PETRUS ANTONIUS DE MAN , RONALD KIM , JIAN LIU , JOSEPH A. KOZLOWSKI , SOBHANA BABU BOGA , THIERRY FISCHMANN , DEODIAL Guy GUIADEEN , ILSE HENDRICA MARIA POLS-DE ROOIJ , SHILAN LIU , HAO WU
Inventor： ADRIANUS PETRUS ANTONIUS DE MAN , RONALD KIM , JIAN LIU , JOSEPH A. KOZLOWSKI , SOBHANA BABU BOGA , THIERRY FISCHMANN , DEODIAL Guy GUIADEEN , ILSE HENDRICA MARIA POLS-DE ROOIJ , SHILAN LIU , HAO WU
IPC: C07D487/04 , A61K31/4985 , A61K31/5377
CPC classification number: C07D487/04 , A61K31/4985 , A61K31/5377 , A61P19/02
Abstract: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.
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公开(公告)号：US20170362242A1
公开(公告)日：2017-12-21
申请号：US15538902
申请日：2015-12-17
Applicant: JIAN LIU , JOSEPH A. KOZLOWSKI , ABDUL-BASIT ALHASSAN , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JYHSHING WANG , WENSHENG YU , JIAQIANG CAI , SHILAN LIU , DAHAI WANG , HAO WU , CHUNDAO YANG
Inventor： JIAN LIU , JOSEPH A. KOZLOWSKI , ABDUL-BASIT ALHASSAN , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JYHSHING WANG , WENSHENG YU , JIAQIANG CAI , SHILAN LIU , DAHAI WANG , HAO WU , CHUNDAO YANG
IPC: C07D487/04 , A61K31/4985 , A61K31/5377 , C07D519/00
CPC classification number: C07D487/04 , A61K31/4985 , A61K31/5377 , A61K45/06 , A61P37/02 , C07D519/00
Abstract: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
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