- 专利标题： MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
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申请号： US18030520申请日： 2021-10-06
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公开(公告)号： US20230373974A1公开(公告)日： 2023-11-23
- 发明人: Jason MCCARTNEY , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Thomas CLEVELAND , Timothy A. DWIGHT , Bryan A. FRIEMAN , Peter GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Mark Thomas MILLER , Alina SILINA , Jinglan ZHOU
- 申请人： VERTEX PHARMACEUTICALS INCORPORATED
- 申请人地址： US MA Boston
- 专利权人： VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人： VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人地址： US MA Boston
- 国际申请： PCT/US2021/053865 2021.10.06
- 进入国家日期： 2023-04-06
- 主分类号： C07D403/12
- IPC分类号： C07D403/12 ; C07D239/70 ; C07D279/08 ; C07D241/44 ; C07D471/04 ; C07D277/82 ; C07D513/04 ; C07D277/84 ; C07D239/84 ; C07D487/04 ; C07D231/56 ; C07D215/38 ; C07D217/22 ; C07D491/048 ; C07D235/30 ; A61K45/06
摘要：
This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the structure: (I), pharmaceutical compositions, containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, combination therapies, and processes and intermediates for making such modulators.
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