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公开(公告)号：US20230374038A1
公开(公告)日：2023-11-23
申请号：US18248068
申请日：2021-10-06
发明人： Jason MCCARTNEY , Alexander Russell ABELA , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Jeremy CLEMENS , Thomas CLEVELAND , Timothy Richard COON , Timothy A. DWIGHT , Bryan A. FRIEMAN , Peter GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Haripada KHATUYA , Paul KRENITSKY , Mark Thomas MILLER , Prasuna PARASELLI , Fabrice PIERRE , Alina SILINA , Joe A. TRAN , Jinglan ZHOU
IPC分类号： C07D515/08 , A61K45/06 , C07D515/18 , A61K31/529 , A61K31/5377
CPC分类号： C07D515/08 , A61K45/06 , C07D515/18 , A61K31/529 , A61K31/5377
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treatment of mediated diseases, such as cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and therapies comprising such modulators, and processes and intermediates for making such modulators.
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公开(公告)号：US20240018161A1
公开(公告)日：2024-01-18
申请号：US18030530
申请日：2021-10-06
发明人： Jason MCCARTNEY , Alexander Russell ABELA , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Jeremy CLEMENS , Thomas CLEVELAND , Timothy Richard COON , Andrew DINH , Timothy A. DWIGHT , Lev Tyler Dewey FANNING , Bryan A. FRIEMAN , Peter GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Paul KRENITSKY , Mark Thomas MILLER , Fabrice PIERRE , Alina SILINA , Joe A. TRAN , Lino VALDEZ , Jinglan ZHOU
IPC分类号： C07D515/04 , C07D515/14 , A61K45/06
CPC分类号： C07D515/04 , A61K45/06 , C07D515/14
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.
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公开(公告)号：US20230373935A1
公开(公告)日：2023-11-23
申请号：US18030518
申请日：2021-10-06
发明人： Jason MCCARTNEY , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Thomas CLEVELAND , Timothy A. DWIGHT , Bryan A. FRIEMAN , Peter GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Mark Thomas MILLER , Alina SILINA , Jinglan ZHOU
IPC分类号： C07D239/69 , C07D401/14 , C07D405/14 , C07D403/12 , C07D403/14 , C07D401/12 , C07D403/04 , C07D409/14 , C07D413/04 , C07D401/04 , C07D413/14 , C07D487/04 , C07D471/04 , C07D417/14 , C07D471/08 , C07D405/04 , C07D409/04 , C07D417/04 , C07D413/10 , C07F9/6558 , C07D409/12 , C07D405/12 , C07D239/47 , C07D413/12 , C07D417/12 , A61K45/06
CPC分类号： C07D239/69 , C07D401/14 , C07D405/14 , C07D403/12 , C07D403/14 , C07D401/12 , C07D403/04 , C07D409/14 , C07D413/04 , C07D401/04 , C07D413/14 , C07D487/04 , C07D471/04 , C07D417/14 , C07D471/08 , C07D405/04 , C07D409/04 , C07D417/04 , C07D413/10 , C07F9/65583 , C07D409/12 , C07D405/12 , C07D239/47 , C07D413/12 , C07D417/12 , A61K45/06
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the core structure, pharmaceutical compositions containing at least one such modulator, methods of treating CFTR mediated diseases, including cystic fibrosis using such modulators and pharmaceutical compositions, combination therapies and combination pharmaceuticals employing those modulators, and processes and intermediates for making such modulators.
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公开(公告)号：US20210032272A1
公开(公告)日：2021-02-04
申请号：US15733738
申请日：2019-04-12
发明人： Alexander Russell ABELA , Jeremy J. CLEMENS , Peter Diederik Jan GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Haripada KHATUYA , Jason McCARTNEY , Mark Thomas MILLER , Fabrice Jean Denis PIERRE , Joe Anh TRAN , Jinglan ZHOU
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis by administering such modulators and pharmaceutical compositions, and processes for making such modulators.
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公开(公告)号：US20230416275A1
公开(公告)日：2023-12-28
申请号：US18030537
申请日：2021-10-06
发明人： Jason MCCARTNEY , Alexander Russell ABELA , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Jeremy CLEMENS , Thomas CLEVELAND , Timothy A. DWIGHT , Bryan A. FRIEMAN , Peter GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Mark Thomas MILLER , Alina SILINA , Jinglan ZHOU
IPC分类号： C07D515/18 , C07D515/22 , C07D515/08 , A61K45/06
CPC分类号： C07D515/18 , C07D515/22 , C07D515/08 , A61K45/06 , C07B2200/09
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.
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公开(公告)号：US20230373939A1
公开(公告)日：2023-11-23
申请号：US18030519
申请日：2021-10-06
发明人： Jason MCCARTNEY , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Thomas CLEVELAND , Timothy A. DWIGHT , Bryan A. FRIEMAN , Peter GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Mark Thomas MILLER , Alina SILINA , Jinglan ZHOU
IPC分类号： C07D279/06 , C07D241/22 , C07D251/24 , C07D239/69 , C07D403/04 , C07D213/76 , C07D401/14 , C07D401/12 , A61K45/06
CPC分类号： C07D279/06 , C07D241/22 , C07D251/24 , C07D239/69 , C07D403/04 , C07D213/76 , C07D401/14 , C07D401/12 , A61K45/06 , C07B2200/05
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the structure: (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, combination therapies, and processes and intermediates for making such modulators.
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公开(公告)号：US20230312616A1
公开(公告)日：2023-10-05
申请号：US17861567
申请日：2022-07-11
发明人： Alexander Russell ABELA , Jeremy J. CLEMENS , Peter Diederik Jan GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Haripada KHATUYA , Jason McCARTNEY , Mark Thomas MILLER , Fabrice Jean Denis PIERRE , Joe Anh TRAN , Jinglan ZHOU
CPC分类号： C07F7/0816 , C07F7/30 , C07F7/083 , C07F7/0814
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.
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公开(公告)号：US20210139514A1
公开(公告)日：2021-05-13
申请号：US17044993
申请日：2019-04-05
发明人： Alexander Russell ABELA , Jeremy J. CLEMENS , Peter Diederik Jan GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Haripada KHATUYA , Jason McCARTNEY , Mark Thomas MILLER , Fabrice Jean Denis PIERRE , Joe Anh TRAN , Jinglan ZHOU
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.
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公开(公告)号：US20240150377A1
公开(公告)日：2024-05-09
申请号：US18248071
申请日：2021-10-06
发明人： Jason MCCARTNEY , Alexander Russell ABELA , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Jeremy CLEMENS , Thomas CLEVELAND , Timothy Richard COON , Timothy A. DWIGHT , Lev Tyler Dewey FANNING , Bryan A. FRIEMAN , Peter GROOTENHUIS , Anton V. GULEVICH , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Haripada KHATUYA , Paul KRENITSKY , Vito MELILLO , Mark Thomas MILLER , Prasuna PARASELLI , Fabrice PIERRE , Alina SILINA , Joe A. TRAN , Johnny UY , Lino VALDEZ , Troy VICKERS , Jinglan ZHOU
IPC分类号： C07D515/08 , A61K31/404 , A61K31/47 , A61K31/529
CPC分类号： C07D515/08 , A61K31/404 , A61K31/47 , A61K31/529
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.
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公开(公告)号：US20230382924A1
公开(公告)日：2023-11-30
申请号：US18030527
申请日：2021-10-06
发明人： Jason MCCARTNEY , Alexander Russell ABELA , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Jeremy CLEMENS , Thomas CLEVELAND , Timothy A. DWIGHT , Bryan A. FRIEMAN , Peter GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Paul KRENITSKY , Mark Thomas MILLER , Fabrice PIERRE , Alina SILINA , Johnny UY , Jinglan Zhou
IPC分类号： C07D515/08 , C07F7/08 , C07F9/6561 , C07D515/18 , C07D515/20 , C07D519/00 , A61K31/47 , A61K31/529 , A61K31/695 , A61K31/675 , A61K31/5377 , A61K31/541
CPC分类号： C07D515/08 , C07F7/0812 , C07F9/6561 , C07D515/18 , C07D515/20 , C07D519/00 , A61K31/47 , A61K31/529 , A61K31/695 , A61K31/675 , A61K31/5377 , A61K31/541 , C07B2200/09
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treating CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination therapies, and processes and intermediates for making such modulators.
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