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公开(公告)号：US20240150377A1
公开(公告)日：2024-05-09
申请号：US18248071
申请日：2021-10-06
发明人： Jason MCCARTNEY , Alexander Russell ABELA , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Jeremy CLEMENS , Thomas CLEVELAND , Timothy Richard COON , Timothy A. DWIGHT , Lev Tyler Dewey FANNING , Bryan A. FRIEMAN , Peter GROOTENHUIS , Anton V. GULEVICH , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Haripada KHATUYA , Paul KRENITSKY , Vito MELILLO , Mark Thomas MILLER , Prasuna PARASELLI , Fabrice PIERRE , Alina SILINA , Joe A. TRAN , Johnny UY , Lino VALDEZ , Troy VICKERS , Jinglan ZHOU
IPC分类号： C07D515/08 , A61K31/404 , A61K31/47 , A61K31/529
CPC分类号： C07D515/08 , A61K31/404 , A61K31/47 , A61K31/529
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.
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公开(公告)号：US20230382924A1
公开(公告)日：2023-11-30
申请号：US18030527
申请日：2021-10-06
发明人： Jason MCCARTNEY , Alexander Russell ABELA , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Jeremy CLEMENS , Thomas CLEVELAND , Timothy A. DWIGHT , Bryan A. FRIEMAN , Peter GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Paul KRENITSKY , Mark Thomas MILLER , Fabrice PIERRE , Alina SILINA , Johnny UY , Jinglan Zhou
IPC分类号： C07D515/08 , C07F7/08 , C07F9/6561 , C07D515/18 , C07D515/20 , C07D519/00 , A61K31/47 , A61K31/529 , A61K31/695 , A61K31/675 , A61K31/5377 , A61K31/541
CPC分类号： C07D515/08 , C07F7/0812 , C07F9/6561 , C07D515/18 , C07D515/20 , C07D519/00 , A61K31/47 , A61K31/529 , A61K31/695 , A61K31/675 , A61K31/5377 , A61K31/541 , C07B2200/09
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treating CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination therapies, and processes and intermediates for making such modulators.
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公开(公告)号：US20220372047A1
公开(公告)日：2022-11-24
申请号：US17600829
申请日：2020-04-02
发明人： Alexander Russell ABELA , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Jeremy CLEMENS , Thomas CLEVELAND , Timothy A. DWIGHT , Bryan A. FRIEMAN , Peter GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Paul KRENITSKY , Jason MCCARTNEY , Vito MELILLO , Mark Thomas MILLER , Alina SILINA , Johnny UY , Jinglan ZHOU
IPC分类号： C07D515/08 , C07D239/69 , C07D215/233 , C07D405/12
摘要： Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.
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公开(公告)号：US20210155643A1
公开(公告)日：2021-05-27
申请号：US16614015
申请日：2018-05-16
IPC分类号： C07F9/58 , C07D213/75 , C07B59/00
摘要： Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. The compounds have the formula (I) wherein R is H or CH2OPO(OH)2. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
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公开(公告)号：US20240018161A1
公开(公告)日：2024-01-18
申请号：US18030530
申请日：2021-10-06
发明人： Jason MCCARTNEY , Alexander Russell ABELA , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Jeremy CLEMENS , Thomas CLEVELAND , Timothy Richard COON , Andrew DINH , Timothy A. DWIGHT , Lev Tyler Dewey FANNING , Bryan A. FRIEMAN , Peter GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Paul KRENITSKY , Mark Thomas MILLER , Fabrice PIERRE , Alina SILINA , Joe A. TRAN , Lino VALDEZ , Jinglan ZHOU
IPC分类号： C07D515/04 , C07D515/14 , A61K45/06
CPC分类号： C07D515/04 , A61K45/06 , C07D515/14
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.
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公开(公告)号：US20230373935A1
公开(公告)日：2023-11-23
申请号：US18030518
申请日：2021-10-06
发明人： Jason MCCARTNEY , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Thomas CLEVELAND , Timothy A. DWIGHT , Bryan A. FRIEMAN , Peter GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Mark Thomas MILLER , Alina SILINA , Jinglan ZHOU
IPC分类号： C07D239/69 , C07D401/14 , C07D405/14 , C07D403/12 , C07D403/14 , C07D401/12 , C07D403/04 , C07D409/14 , C07D413/04 , C07D401/04 , C07D413/14 , C07D487/04 , C07D471/04 , C07D417/14 , C07D471/08 , C07D405/04 , C07D409/04 , C07D417/04 , C07D413/10 , C07F9/6558 , C07D409/12 , C07D405/12 , C07D239/47 , C07D413/12 , C07D417/12 , A61K45/06
CPC分类号： C07D239/69 , C07D401/14 , C07D405/14 , C07D403/12 , C07D403/14 , C07D401/12 , C07D403/04 , C07D409/14 , C07D413/04 , C07D401/04 , C07D413/14 , C07D487/04 , C07D471/04 , C07D417/14 , C07D471/08 , C07D405/04 , C07D409/04 , C07D417/04 , C07D413/10 , C07F9/65583 , C07D409/12 , C07D405/12 , C07D239/47 , C07D413/12 , C07D417/12 , A61K45/06
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the core structure, pharmaceutical compositions containing at least one such modulator, methods of treating CFTR mediated diseases, including cystic fibrosis using such modulators and pharmaceutical compositions, combination therapies and combination pharmaceuticals employing those modulators, and processes and intermediates for making such modulators.
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公开(公告)号：US20210032272A1
公开(公告)日：2021-02-04
申请号：US15733738
申请日：2019-04-12
发明人： Alexander Russell ABELA , Jeremy J. CLEMENS , Peter Diederik Jan GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Haripada KHATUYA , Jason McCARTNEY , Mark Thomas MILLER , Fabrice Jean Denis PIERRE , Joe Anh TRAN , Jinglan ZHOU
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis by administering such modulators and pharmaceutical compositions, and processes for making such modulators.
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8.发明申请Pyrrolopyrazine-Spirocyclic piperidine amides as modulators of ion channels 有权吡咯并吡嗪 - 螺环哌啶酰胺作为离子通道的调节剂公开(公告)号：US20150174127A1
公开(公告)日：2015-06-25
申请号：US14578628
申请日：2014-12-22
发明人： Sara Sabina HADIDA RUAH , Edward Adam KALLEL , Mark Thomas MILLER , Vijayalaksmi ARUMUGAM , Jason McCARTNEY , Corey ANDERSON , Peter Diederik Jan GROOTENHUIS , Licong JIANG
IPC分类号： A61K31/499 , A61K31/506
CPC分类号： C07D471/20 , A61K31/499 , A61K31/506 , C07D519/00
摘要： The invention relates to pyrrolopyrazine-spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的吡咯并吡嗪 - 螺环哌啶酰胺化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20230382925A1
公开(公告)日：2023-11-30
申请号：US18030529
申请日：2021-10-06
发明人： Jason MCCARTNEY , Alexander Russell ABELA , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Jeremy CLEMENS , Thomas CLEVELAND , Timothy Richard COON , Timothy A. DWIGHT , Lev Tyler Dewey FANNING , Bryan A. FRIEMAN , Peter GROOTENHUIS , Anton V. GULEVICH , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Haripada KHATUYA , Paul KRENITSKY , Vito MELILLO , Mark Thomas MILLER , Prasuna PARASELLI , Fabrice PIERRE , Alina SILINA , Joe A. TRAN , Johnny UY , Lino VALDEZ , Jinglan ZHOU
IPC分类号： C07D515/08 , A61K45/06
CPC分类号： C07D515/08 , A61K45/06
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.
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公开(公告)号：US20230373974A1
公开(公告)日：2023-11-23
申请号：US18030520
申请日：2021-10-06
发明人： Jason MCCARTNEY , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Thomas CLEVELAND , Timothy A. DWIGHT , Bryan A. FRIEMAN , Peter GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Mark Thomas MILLER , Alina SILINA , Jinglan ZHOU
IPC分类号： C07D403/12 , C07D239/70 , C07D279/08 , C07D241/44 , C07D471/04 , C07D277/82 , C07D513/04 , C07D277/84 , C07D239/84 , C07D487/04 , C07D231/56 , C07D215/38 , C07D217/22 , C07D491/048 , C07D235/30 , A61K45/06
CPC分类号： C07D403/12 , C07D239/70 , C07D279/08 , C07D241/44 , C07D471/04 , C07D277/82 , C07D513/04 , C07D277/84 , C07D239/84 , C07D487/04 , C07D231/56 , C07D215/38 , C07D217/22 , C07D491/048 , C07D235/30 , A61K45/06
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the structure: (I), pharmaceutical compositions, containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, combination therapies, and processes and intermediates for making such modulators.
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