This disclosure provides systems, devices, apparatus, and methods, including computer programs encoded on storage media, for runtime optimization of the shader execution flow. A graphics processor may obtain instruction execution data associated with a graphics workload, the instruction execution data including graphics data for a set of shader operations. The graphics processor may configure, at a first iteration, at least one predication value based on the instruction execution data including the graphics data for the set of shader operations. The graphics processor may adjust, at a second iteration, an execution flow of the graphics workload based on the configured at least one predication value, the execution flow of the graphics workload including the set of shader operations. The graphics processor may execute or refrain from executing, at the second iteration, each of the set of shader operations based on the adjusted execution flow of the graphics workload.