Provided herein is technology for cervical cancer screening. In particular, provided herein are methods, compositions, and related uses for detecting the presence or absence of cervical cancer, cervical pre-cancers (e.g., cervix related in-situ adenocarcinoma, cervical intraepithelial neoplasia), and cervical cancer subtypes (e.g., cervical adenocarcinoma, squamous cell cervical cancer), or for discriminating cervical cancer from other types of gynecological cancers (e.g., endometrial, and ovarian cancers) from a biological sample (e.g., a tissue sample (e.g., cervical tissue), a blood sample, a plasma sample, a serum sample, a whole blood sample, a secretion sample (e.g., cervical secretion, vaginal secretion), an organ secretion sample, a CSF sample, a saliva sample, a urine sample, or a stool sample).