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公开(公告)号：US11702704B2
公开(公告)日：2023-07-18
申请号：US17085542
申请日：2020-10-30
发明人： William R. Taylor , John B. Kisiel , Douglas W. Mahoney , David A. Ahlquist , Hatim T. Allawi , Michael W. Kaiser
IPC分类号： C12Q1/6886 , C12Q1/6869 , C12N15/117 , G01N33/50
CPC分类号： C12Q1/6886 , C12N15/117 , C12Q1/6869 , G01N33/50 , C12Q2521/301 , C12Q2523/125
摘要： Provided herein is technology for ovarian cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of ovarian cancer and sub-types of ovarian cancer (e.g., clear cell ovarian cancer, endometrioid ovarian cancer, mucinous ovarian cancer, serous ovarian cancer).
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公开(公告)号：US11697853B2
公开(公告)日：2023-07-11
申请号：US17144806
申请日：2021-01-08
发明人： David A. Ahlquist , William R. Taylor , John B. Kisiel , Tracy C. Yab , Douglas W. Mahoney , Brian A. Dukek , Matthew T. Gettman , Hatim T. Allawi
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/16
摘要： Provided herein is technology for prostate cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of prostate cancer.
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公开(公告)号：US20230028856A1
公开(公告)日：2023-01-26
申请号：US17811677
申请日：2022-07-11
IPC分类号： C12Q1/6886
摘要： Provided herein is technology for gastrointestinal neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of gastrointestinal neoplasm, and classifying the site location of such a gastrointestinal neoplasm (e.g., a colorectal region, a pancreaticobiliary region, a gastroesophageal region).
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公开(公告)号：US11118228B2
公开(公告)日：2021-09-14
申请号：US15881409
申请日：2018-01-26
发明人： Hatim T. Allawi , Michael W. Kaiser , Graham P. Lidgard , William R. Taylor , Tamara J. Sander , Abram M. Vaccaro
IPC分类号： C12Q1/6883 , C12Q1/6886 , G01N33/533 , G16Z99/00 , C12Q1/6809 , C12Q1/6827 , C12Q1/6853 , G01N33/574
摘要： Provided herein is technology for neoplasia screening, and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of cancer, in particular, colorectal cancer.
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公开(公告)号：US11104960B2
公开(公告)日：2021-08-31
申请号：US16570782
申请日：2019-09-13
发明人： David A. Ahlquist , William R. Taylor , John B. Kisiel , Douglas W. Mahoney , Tracy C. Yab , Graham P. Lidgard , Hatim T. Allawi
IPC分类号： C07H21/04 , C12Q1/68 , C12Q1/6886 , C12Q1/6883 , G01N33/574
摘要： Provided herein is technology for esophageal disorder screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal disorders (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). In addition, the technology provides methods, compositions and related uses for distinguishing between Barrett's esophagus and Barrett's esophageal dysplasia, and between Barrett's esophageal low-grade dysplasia, Barrett's esophageal high-grade dysplasia, and esophageal adenocarcinoma within samples obtained through endoscopic brushing or nonendoscopic whole esophageal brushing or swabbing using a tethered device (e.g. such as a capsule sponge, balloon, or other device).
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公开(公告)号：US10683555B2
公开(公告)日：2020-06-16
申请号：US15978565
申请日：2018-05-14
发明人： David A. Ahlquist , John B. Kisiel , William R. Taylor , Tracy C. Yab , Douglas W. Mahoney , Graham P. Lidgard , Hatim T. Allawi
IPC分类号： C07H21/04 , C12Q1/68 , C12Q1/6886
摘要： Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer.
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公开(公告)号：US10184154B2
公开(公告)日：2019-01-22
申请号：US14864158
申请日：2015-09-24
IPC分类号： C12Q1/68 , C12Q1/6886
摘要： Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting neoplasms such as cholangiocarinoma.
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公开(公告)号：US20180320240A1
公开(公告)日：2018-11-08
申请号：US16030313
申请日：2018-07-09
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154
摘要： Provided herein is technology for gastrointestinal neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of gastrointestinal neoplasm, and classifying the site location of such a gastrointestinal neoplasm (e.g., a colorectal region, a pancreaticobiliary region, a gastroesophageal region).
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公开(公告)号：US20180245157A1
公开(公告)日：2018-08-30
申请号：US15881409
申请日：2018-01-26
发明人： Hatim T. Allawi , Michael W. Kaiser , Graham P. Lidgard , William R. Taylor , Tamara J. Sander , Abram M. Vaccaro
IPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q1/6853 , C12Q1/6809
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q1/6827 , C12Q1/6853 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156 , C12Q2600/16 , G01N33/533 , G01N33/57419 , G16Z99/00
摘要： Provided herein is technology for neoplasia screening, and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of cancer, in particular, colorectal cancer.
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公开(公告)号：US09994911B2
公开(公告)日：2018-06-12
申请号：US14775435
申请日：2014-03-12
发明人： David A. Ahlquist , John B. Kisiel , William R. Taylor , Tracy C. Yab , Douglas W. Mahoney , Graham P. Lidgard , Hatim T. Allawi
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154
摘要： Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer. Accordingly, provided herein is technology for pancreatic cancer screening markers and other gastrointestinal cancer screening markers that provide a high signal to-noise ratio and a low background level when detected from samples taken from a subject (e.g., stool sample). As described herein, the technology provides a number of methylated DNA markers and subsets thereof (e.g., sets of 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or more markers) with high discrimination for G1 neoplasms overall and/or at individual tumor sites.
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