- 专利标题: MUTANT DNA POLYMERASE(S) WITH IMPROVED STRAND DISPLACEMENT ABILITY
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申请号: US18219045申请日: 2023-07-06
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公开(公告)号: US20240110162A1公开(公告)日: 2024-04-04
- 发明人: Feruz Kurbanov
- 申请人: Roche Molecular Systems, Inc.
- 申请人地址: US CA Pleasanton
- 专利权人: Roche Molecular Systems, Inc.
- 当前专利权人: Roche Molecular Systems, Inc.
- 当前专利权人地址: US CA Pleasanton
- 主分类号: C12N9/12
- IPC分类号: C12N9/12 ; C12Q1/6844
摘要:
Disclosed are DNA polymerases having increased 5′-3′ strand displacement activity and substantially reduced 5′-3′ exonuclease and endonuclease activity relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.
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