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公开(公告)号：US20230128368A1
公开(公告)日：2023-04-27
申请号：US17865159
申请日：2022-07-14
IPC分类号： C12Q1/6841 , C12Q1/6876 , C12Q1/6886
摘要： The present disclosure relates to a set of at least 100 single-stranded oligonucleotide probes directed against (or complementary to) portions of a genomic target sequence of interest. The present disclosure also relates to a method of detecting a genomic target sequence of interest using the set of oligonucleotide probes and a method of generating the set of oligonucleotide probes. Further, the present disclosure relates to a kit comprising the set of oligonucleotide probes and at least one further component.
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公开(公告)号：USD978370S1
公开(公告)日：2023-02-14
申请号：US29762428
申请日：2020-12-16
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公开(公告)号：USD974391S1
公开(公告)日：2023-01-03
申请号：US29766573
申请日：2021-01-15
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公开(公告)号：US11505830B2
公开(公告)日：2022-11-22
申请号：US15993375
申请日：2018-05-30
发明人： Ann Begovich , Cindy Cheung , Javelin Chi , Grantland Hillman , Dwight Kuo , Michael Lee , Chitra Manohar , Xiaoju Max Ma , Ellen Ordinario , Jaya Rajamani , Huan Truong
IPC分类号： C12Q1/6886 , C12Q1/6851 , C12Q1/686
摘要： Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions, optionally in combination with other mutations and fusions.
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公开(公告)号：USD969838S1
公开(公告)日：2022-11-15
申请号：US29733475
申请日：2020-05-03
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公开(公告)号：US11462325B2
公开(公告)日：2022-10-04
申请号：US16588289
申请日：2019-09-30
发明人： Antoaneta Petkova Vladimirova , Yogesh P. Pandit , Vishakha Sharma , Tod M. Klingler , Hari Singhal
IPC分类号： G16H50/20 , G16H20/30 , G16H10/40 , G16H15/00 , G16H50/30 , G16B40/00 , G16B20/00 , G06T7/00 , G06V20/69
摘要： Methods and systems for performing a clinical prediction are provided. In one example, the method comprises: receiving first molecular data of a patient, the first molecular data including at least gene expressions of the patient; receiving first biopsy image data of the patient; processing, using a machine learning model, the first molecular data and the first biopsy image data to perform a clinical prediction of the patient's response to a treatment, wherein the machine learning model is generated or updated based on second molecular data including at least gene expressions and second biopsy image data of a plurality of patients; and generating an output of the clinical prediction.
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公开(公告)号：US20220301670A1
公开(公告)日：2022-09-22
申请号：US17639441
申请日：2020-09-08
摘要： In one example, a method being performed by a computer system comprises: receiving an image file containing a pathology report; performing an image recognition operation on the image file to extract input text strings; detecting, using a natural language processing (NLP) model, entities from the input text strings, each entity including a label and a value; extracting, using the NLP model, the values of the entities from the input text strings; converting, based on a mapping table that maps entities and values to pre-determined terminologies, the values of at least some of the entities to the corresponding pre-determined terminologies; and generating a post-processed pathology report including the entities detected from the input text strings and the corresponding pre-determined terminologies.
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公开(公告)号：US20220290221A1
公开(公告)日：2022-09-15
申请号：US17692955
申请日：2022-03-11
发明人： Chitra Manohar , Marcel R. Fontecha , Christopher David Santini , Eugene Spier , Jingtao Sun , Michelle Elizabeth Yee , Kalyani Mangipudi
IPC分类号： C12Q1/6858 , C12Q1/6869 , C12Q1/6888
摘要： Methods for the rapid detection of the presence of variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that contain mutations in the Spike (S) protein gene in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers and probes targeting SARS-CoV-2 variants containing S gene mutations and kits are provided that are designed for the detection of SARS-CoV-2 variants containing S gene mutations.
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公开(公告)号：US11421266B2
公开(公告)日：2022-08-23
申请号：US16830050
申请日：2020-03-25
IPC分类号： C07H21/02 , C12Q1/6841 , C12Q1/6876 , C12Q1/6886
摘要： The present disclosure relates to a set of at least 100 single-stranded oligonucleotide probes directed against (or complementary to) portions of a genomic target sequence of interest. The present disclosure also relates to a method of detecting a genomic target sequence of interest using the set of oligonucleotide probes and a method of generating the set of oligonucleotide probes. Further, the present disclosure relates to a kit comprising the set of oligonucleotide probes and at least one further component.
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公开(公告)号：US11385170B2
公开(公告)日：2022-07-12
申请号：US15671334
申请日：2017-08-08
发明人： Michael Zeder
摘要： The present disclosure provides a plate comprising an array of wells for chemical or biological reactions, wherein each of the wells comprises a reaction chamber with at least one opening on a surface of the plate. The array of wells consist of a plurality of adjacent blocks of wells, wherein each block of wells consists of a plurality of adjacent rows of wells, and wherein at least one void is provided in each block of wells in between the rows of wells. Here, the void is particularly part of the surface of the plate and lacks a well opening. Furthermore, a method for multiple imaging of such a plate by means of an imaging system is provided with the present disclosure.
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