An IMC circuit includes a memory cells arranged in matrix. Computational weights for an IMC operation are stored in groups of cells. Each row of groups of cells includes a positive and negative word linen. Each column of groups of cells includes a bit line. The IMC operation includes a first elaboration where a word line signal is applied to the positive/negative word line of the group of cells depending on the positive/negative sign, respectively, of the coefficient data, with a positive MAC output on the bit line. In a second elaboration, a word line signal is applied to the negative/positive word line of the group of cells depending on the positive/negative sign, respectively, of the coefficient data, with a negative MAC output on the bit line. The IMC operation result is obtained from a difference between the positive and negative MAC operations.