Techniques for implementing programmable control by a guest virtual machine (VM) of interrupts at a processing system using a guest owned backing page are disclosed. The VM programs a guest owned backing page (e.g., a data structure in memory) that designates particular interrupts that are to be blocked. In response to detecting a designated interrupt, system hardware or software blocks the interrupt, rather than executing an interrupt handler to process the interrupt. The VM is thereby able to protect confidential information and program behavior with less risk of a malicious hypervisor failing to protect the VM from, e.g., unexpected or unwanted interrupts, thereby improving overall system security and predictability.