Disclosed are adipose matrices comprising devitalized, or vitalized, and partially delipidized adipose tissue. Disclosed are compositions comprising an adipose matrix comprising devitalized, or vitalized, and partially delipidized adipose tissue. Disclosed are compositions comprising an adipose matrix comprising devitalized, or vitalized, and partially delipidized adipose tissue and MSCs. Disclosed are methods of making any of the disclosed adipose matrices or compositions. Disclosed are methods of treating a subject having a metabolic liver disease, metabolic disease, ischemic wound, or inflammatory disease comprising administering to the subject a therapeutically effective amount of a composition disclosed herein. Disclosed are methods of decreasing cholesterol in a subject comprising administering to the subject a therapeutically effective amount of a composition disclosed herein. Disclosed are methods of decreasing lipids in the liver of a subject comprising administering to the subject a therapeutically effective amount of a composition disclosed herein.