公开(公告)号：US20240335530A1

公开(公告)日：2024-10-10

申请号：US18743581

申请日：2024-06-14

申请人： CALIDI BIOTHERAPEUTICS (NEVADA), INC.

发明人： Aladar SZALAY ,  Boris Minev

IPC分类号： A61K39/285 ,  A61K35/35 ,  A61K35/76 ,  A61K39/00 ,  A61K39/12

CPC分类号： A61K39/285 ,  A61K35/35 ,  A61K35/76 ,  A61K39/12 ,  A61K2039/515 ,  A61K2039/525 ,  A61K2039/5254 ,  A61K2039/55 ,  A61K2039/585 ,  A61K2039/6006 ,  C12N2710/24134

摘要： Disclosed herein are methods and compositions related to therapy for cancer. More specifically, the disclosed methods and compositions are related to the use of smallpox vaccine to induce an effective anti-tumor immune response.

公开(公告)号：US20240252548A1

公开(公告)日：2024-08-01

申请号：US18578959

申请日：2022-07-13

申请人： BRITECYTE INC.

发明人： Alla DANILKOVITCH

IPC分类号： A61K35/35 ,  A61K9/00 ,  A61K35/12 ,  A61K35/28 ,  A61P1/16 ,  A61P3/06

CPC分类号： A61K35/35 ,  A61K9/0019 ,  A61K35/28 ,  A61P1/16 ,  A61P3/06 ,  A61K2035/122

摘要： Disclosed are adipose matrices comprising devitalized, or vitalized, and partially delipidized adipose tissue. Disclosed are compositions comprising an adipose matrix comprising devitalized, or vitalized, and partially delipidized adipose tissue. Disclosed are compositions comprising an adipose matrix comprising devitalized, or vitalized, and partially delipidized adipose tissue and MSCs. Disclosed are methods of making any of the disclosed adipose matrices or compositions. Disclosed are methods of treating a subject having a metabolic liver disease, metabolic disease, ischemic wound, or inflammatory disease comprising administering to the subject a therapeutically effective amount of a composition disclosed herein. Disclosed are methods of decreasing cholesterol in a subject comprising administering to the subject a therapeutically effective amount of a composition disclosed herein. Disclosed are methods of decreasing lipids in the liver of a subject comprising administering to the subject a therapeutically effective amount of a composition disclosed herein.

公开(公告)号：US20240084258A1

公开(公告)日：2024-03-14

申请号：US18517402

申请日：2023-11-22

申请人： KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION

发明人： Kenta YAMAMOTO ,  Tsunao Kishida ,  Toshiro Yamamoto ,  Osam Mazda

IPC分类号： C12N5/077 ,  A61K35/35

CPC分类号： C12N5/0653 ,  A61K35/35 ,  C12N2501/01 ,  C12N2501/15 ,  C12N2501/30 ,  C12N2501/727 ,  C12N2501/999 ,  C12N2506/1307

摘要： The present invention aims to provide a brown adipocyte and a generation method thereof, a transplantation material containing a brown adipocyte, a prophylactic agent or therapeutic agent containing a brown adipocyte for various diseases and conditions, and use thereof. Provided is a method for generating a brown adipocyte, including converting a differentiated somatic cell of a mammal to a brown adipocyte by culturing the somatic cell in a medium in the presence of at least one kind of a compound selected from the group consisting of (1) a TGFβ/SMAD pathway inhibitor, (2) a casein kinase 1 inhibitor, (3) a cAMP inducer and (4) a MEK/ERK pathway inhibitor.

公开(公告)号：US20240050985A1

公开(公告)日：2024-02-15

申请号：US17888401

申请日：2022-08-15

申请人： N.S. UNI-GLOVES SDN. BHD.

发明人： SEE KEONG WONG ,  PEK WEE WONG

IPC分类号： B05D7/24 ,  B05D3/10 ,  B05D3/02 ,  B05D7/02 ,  C08L7/02 ,  A61K9/00 ,  A61K35/35 ,  A61K31/355

CPC分类号： B05D7/24 ,  B05D3/101 ,  B05D3/0254 ,  B05D7/02 ,  C08L7/02 ,  A61K9/0014 ,  A61K35/35 ,  A61K31/355

摘要： A process for creating a disposable glove which has been specially treated with a uniform coating of the Lanolin and Vitamin-E composite through a specially controlled application and drying process. The process satisfies the need to minimize the side effects of skin damage and irritation due to prolonged and extensive application of hand gloves in the health care industry.

公开(公告)号：US20240016851A1

公开(公告)日：2024-01-18

申请号：US18372903

申请日：2023-09-26

申请人： Jointechlabs, Inc.

发明人： Nathan Katz ,  Nishit Pancholi

IPC分类号： A61K35/28 ,  A61K35/35 ,  B01L3/00 ,  B33Y10/00 ,  B33Y70/00 ,  B04B3/00 ,  B01D21/00 ,  B01D21/26 ,  A61L27/36

CPC分类号： A61K35/28 ,  A61K35/35 ,  B01L3/5021 ,  B33Y10/00 ,  B33Y70/00 ,  B04B3/00 ,  B01D21/0012 ,  B01D21/262 ,  A61L27/3691 ,  B01L2300/0832 ,  B01L2200/025 ,  B01D2221/10 ,  A61L2430/40 ,  B01L2300/0681

摘要： A device that allows for either fat graft preparation or cell fraction harvest is disclosed. The device includes a first centrifuge tube configured to receive and process a biological substance, the first centrifuge tube comprising an upper cylindrical portion and a lower conical portion, a sterile tissue inlet fitting, at least one sterile processing fluid inlet fitting, a sterile suction fitting, and at least one sterile extraction port connected to a first extraction tube. The first centrifuge tube further includes an internal space including a screen being positioned therein, the screen being configured to divide the internal space in half, and a filter positioned therein, the filter being positioned below the screen in the lower conical portion of the first centrifuge tube. The device may further include a second centrifuge tube configured to receive and further process the biological substance from the first centrifuge tube. The second centrifuge tube has at least one sterile fitting, wherein the second centrifuge tube is releasably connected via the at least one sterile fitting to one of the at least one sterile extraction ports of the first centrifuge tube.

公开(公告)号：US20240000852A1

公开(公告)日：2024-01-04

申请号：US18039639

申请日：2021-11-30

申请人： SHANGHAI SEME CELL TECHNOLOGY CO., LTD.

发明人： Zhifeng YU ,  Mingming XU ,  Wenjie ZHANG

IPC分类号： A61K35/35 ,  A61P19/10

CPC分类号： A61K35/35 ,  A61P19/10

摘要： A cell-free fat extract is used for the preparation of a composition or a formulation. The composition or the formulation is effective in (i) preventing and/or treating osteoporosis; (ii) increasing bone volume fraction; (iii) increasing trabecular number; (iv) increasing trabecular connectivity density; (v) increasing bone mineral density; (vi) increasing trabecular thickness; and/or (vii) reducing trabecular separation.

公开(公告)号：US11857575B2

公开(公告)日：2024-01-02

申请号：US15772668

申请日：2016-11-02

申请人： Takeda Pharmaceutical Company Limited

发明人： Olga De La Rosa ,  Eleuterio Lombardo ,  Wilfried Dalemans ,  Javier Garcia Casado ,  Rebeca Blazquez Duran ,  Francisco Miguel Sanchez Margallo

IPC分类号： A61K35/02 ,  A61K9/127 ,  A61K9/50 ,  C12N15/62 ,  A61P29/00 ,  A61P37/06 ,  A61K45/06 ,  A61K35/35 ,  A61K31/519 ,  A61K31/4709 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/5377 ,  G01N1/40 ,  C12N5/0775 ,  A61K35/12 ,  A61K35/28

CPC分类号： A61K35/28 ,  A61K9/127 ,  A61K9/5068 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/519 ,  A61K31/5377 ,  A61K35/35 ,  A61K45/06 ,  A61P29/00 ,  A61P37/06 ,  C12N15/625 ,  A61K2035/122 ,  A61K2035/128 ,  A61K2300/00 ,  C12N5/0667 ,  G01N1/4077 ,  A61K31/4709 ,  A61K2300/00 ,  A61K31/5377 ,  A61K2300/00 ,  A61K31/4439 ,  A61K2300/00 ,  A61K31/444 ,  A61K2300/00 ,  A61K31/519 ,  A61K2300/00 ,  A61K35/28 ,  A61K2300/00

摘要： The invention relates to exosomes derived from mesenchymal stem cells and well as isolated populations of said exosomes and method for preparing said isolated exosome populations. The invention also relates to a pharmaceutical composition comprising said exosome or isolated exosome population and their use in a method of treating an immune-mediated inflammatory disease in a subject.

公开(公告)号：US11851682B2

公开(公告)日：2023-12-26

申请号：US17348218

申请日：2021-06-15

申请人： BioRestorative Therapies, Inc.

发明人： Francisco Javier Silva ,  Mark Weinreb ,  Amit N. Patel ,  David A. Bull

IPC分类号： C12N5/0775 ,  C12N5/077 ,  G01N33/50 ,  A61K35/35 ,  A61K35/28

CPC分类号： C12N5/0667 ,  A61K35/35 ,  C12N5/0653 ,  G01N33/502 ,  G01N33/5044 ,  A61K35/28 ,  C12N2500/84 ,  C12N2500/98 ,  C12N2501/01 ,  C12N2501/02 ,  C12N2501/33 ,  C12N2501/385 ,  C12N2501/39 ,  C12N2501/395 ,  C12N2506/1384 ,  Y02A50/30

摘要： Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment, the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods of using such cell lines to screen for compounds that play a role in regulating a variety of processes.

公开(公告)号：US20230233601A1

公开(公告)日：2023-07-27

申请号：US18011164

申请日：2021-07-05

申请人： Sadanand Prabhakar SARDESHMUKH

发明人： Sadanand Prabhakar SARDESHMUKH ,  Vineeta Vasant DESHMUKH

IPC分类号： A61K33/242 ,  A61K33/10 ,  A61K31/718 ,  A61K36/71 ,  A61K47/36 ,  A61K35/618 ,  A61K35/614 ,  A61K35/35 ,  A61K9/20 ,  A61P35/00

CPC分类号： A61K33/242 ,  A61K33/10 ,  A61K31/718 ,  A61K36/71 ,  A61K47/36 ,  A61K35/618 ,  A61K35/614 ,  A61K35/35 ,  A61K9/2072 ,  A61K9/2095 ,  A61P35/00

摘要： The present disclosure relates to a herbo-mineral metallic pharmaceutical kit and a process for its preparation. The herbo-mineral metallic pharmaceutical kit comprises Suvarna Bhasmadi Vati (SBV), Mouktikyukta Kamdudha Vati (MKV), Trailokyachintamani Rasa Vati (TCR), Kumari Kalpa Vati (KKV) and Khadirarishta (KHA). The herbo-mineral metallic pharmaceutical kit of the present disclosure can be used for delaying and/or controlling the recurrence or occurrence of breast and/or ovarian cancer in second breast and/or ovary or metastasis. The herbo-mineral metallic pharmaceutical compositions of the kit assist in reducing oxidative stress, improving immune status and quality of life and maintaining a disease-free survival in patients who are genetically predisposed to breast or ovarian cancer.

公开(公告)号：US11666605B2

公开(公告)日：2023-06-06

申请号：US17129642

申请日：2020-12-21

申请人： GID BIO, Inc.

发明人： William W. Cimino ,  Adam J. Katz ,  Ramon Llull

IPC分类号： C12M1/06 ,  A61K35/35 ,  C12M1/00 ,  A61K45/06 ,  C12N5/077 ,  A61K35/12 ,  A61M1/00

CPC分类号： A61K35/35 ,  A61K35/12 ,  A61K45/06 ,  A61M1/60 ,  A61M1/892 ,  C12M27/02 ,  C12M45/09 ,  C12N5/0653 ,  A61M2202/08 ,  A61M2205/75

摘要： Preparation of a product comprising stromal vascular fraction cells includes washing human biological material comprising adipose in a container apparatus having an internal filter, which divides an internal containment volume of the container apparatus into a tissue retention volume on one side of the filter and a filtrate volume on an opposite side of the filter, and a mixing device with at least one rotatable mixing member disposed in the tissue retention volume. The washing includes operation of the mixing device to rotate the mixing member through the human biological material within the tissue retention volume, and the washing is followed by digesting washed material within the internal containment volume with added enzyme, centrifuging of the container apparatus to prepare a centrifuged pellet in the filtrate volume, selectively removing material of the pellet and preparing a product with a mixture of stromal vascular fraction cells of removed pellet material and an aqueous suspension liquid.