Provided herein is a system including a pre-filled syringe with a barrel defining a chamber containing a solution therein and a fluid connector component at the distal end of the barrel. A plunger assembly including a plunger and a stopper is movable within the barrel, with the plunger including a channel extending along a length thereof. An access device is positioned at the proximal end of the plunger and includes a receiving cavity and a fluid access component, the receiving cavity having an opening aligned with the channel and the fluid access component positioned over the opening and extending into the receiving cavity. A cannula is positioned within the barrel and extends through the stopper, the cannula placing the fluid connector component in fluid communication with the channel. A closure assembly is secured to the fluid connector component and includes a seal member configured to seal off a lumen thereof.