Invention Grant
US3594477A Optically active pyridine derivatives in pharmaceutical compositions and their use as analgesics and stimulants
失效
药物组合物中的光学活性吡啶衍生物及其作为药物和刺激物的用途
- Patent Title: Optically active pyridine derivatives in pharmaceutical compositions and their use as analgesics and stimulants
- Patent Title (中): 药物组合物中的光学活性吡啶衍生物及其作为药物和刺激物的用途
-
Application No.: US3594477DApplication Date: 1969-01-14
-
Publication No.: US3594477APublication Date: 1971-07-20
- Inventor: WOLLWEBER HARTMUND , HILTMANN RUDOLF , HOFFMEISTER FRIEDRICH , KRONEBERG HANS-GUENTHER
- Applicant: BAYER AG
- Assignee: Bayer Ag
- Current Assignee: Bayer Ag
- Priority: DEF0046713 1965-07-24
- Main IPC: A61K31/44
- IPC: A61K31/44 ; C07D401/12 ; A61K27/00
Abstract:
DEXTRO-ROTATORY AND LEVO-ROTATORY ISOMERS OF N-ACYL-N(2''-PYRIDYL)-1-PIPERIDINO-2-AMINOPROPANES OF THE FORMULA:
2-(PIPERIDINO-CH2-CH(-CH3)-N(-CO-R)-)PYRIDINE
WHEREIN R IS METHYL OR ETHYL OR A PHARMACEUTICALLY ACCEPTABLE NON-TOXIC ACID SALT THEREOF EXHIBIT PHARMACEUTICAL PROPERTIES WHICH DIFFER QUALITATIVELY FROM THE RACEMATE. THE L-ISOMER EXHIBITS APPROXIMATELY THE SAME ANALGESIC ACTIVITY AS THE RACEMATE BUT ALSO EXHIBITS A STRONG SEDATIVE EFFECT. THE D-ISOMER EXHIBITS APPROXIMATELY THE SAME ANALGESIC ACTIVITY AS THE RACEMATE BUT EXHIBITS ALSO A CENTRAL NERVOUS SYSTEM STIMULANT EFFECT.
2-(PIPERIDINO-CH2-CH(-CH3)-N(-CO-R)-)PYRIDINE
WHEREIN R IS METHYL OR ETHYL OR A PHARMACEUTICALLY ACCEPTABLE NON-TOXIC ACID SALT THEREOF EXHIBIT PHARMACEUTICAL PROPERTIES WHICH DIFFER QUALITATIVELY FROM THE RACEMATE. THE L-ISOMER EXHIBITS APPROXIMATELY THE SAME ANALGESIC ACTIVITY AS THE RACEMATE BUT ALSO EXHIBITS A STRONG SEDATIVE EFFECT. THE D-ISOMER EXHIBITS APPROXIMATELY THE SAME ANALGESIC ACTIVITY AS THE RACEMATE BUT EXHIBITS ALSO A CENTRAL NERVOUS SYSTEM STIMULANT EFFECT.
Information query
