公开(公告)号：US3594477A

公开(公告)日：1971-07-20

申请号：US3594477D

申请日：1969-01-14

Applicant: BAYER AG

Inventor： WOLLWEBER HARTMUND ,  HILTMANN RUDOLF ,  HOFFMEISTER FRIEDRICH ,  KRONEBERG HANS-GUENTHER

IPC: A61K31/44 ,  C07D401/12 ,  A61K27/00

CPC classification number: C07D401/12 ,  A61K31/44

Abstract: DEXTRO-ROTATORY AND LEVO-ROTATORY ISOMERS OF N-ACYL-N(2''-PYRIDYL)-1-PIPERIDINO-2-AMINOPROPANES OF THE FORMULA:

2-(PIPERIDINO-CH2-CH(-CH3)-N(-CO-R)-)PYRIDINE

WHEREIN R IS METHYL OR ETHYL OR A PHARMACEUTICALLY ACCEPTABLE NON-TOXIC ACID SALT THEREOF EXHIBIT PHARMACEUTICAL PROPERTIES WHICH DIFFER QUALITATIVELY FROM THE RACEMATE. THE L-ISOMER EXHIBITS APPROXIMATELY THE SAME ANALGESIC ACTIVITY AS THE RACEMATE BUT ALSO EXHIBITS A STRONG SEDATIVE EFFECT. THE D-ISOMER EXHIBITS APPROXIMATELY THE SAME ANALGESIC ACTIVITY AS THE RACEMATE BUT EXHIBITS ALSO A CENTRAL NERVOUS SYSTEM STIMULANT EFFECT.

公开(公告)号：US3505321A

公开(公告)日：1970-04-07

申请号：US3505321D

申请日：1968-12-09

Applicant: BAYER AG

Inventor： SCHUTZ SIEGISMUND ,  HOFFMEISTER FRIEDRICH

IPC: C07D295/12 ,  C07D87/40

CPC classification number: C07D295/12

公开(公告)号：US3865834A

公开(公告)日：1975-02-11

申请号：US32127873

申请日：1973-01-05

Applicant: BAYER AG

Inventor： SCHUBERT HANS-WERNER ,  BEHNER OTTO ,  HOFFMEISTER FRIEDRICH

IPC: C07D221/26 ,  C07D39/00

CPC classification number: C07D221/26

Abstract: Benzomorphans of the formula:

WHEREIN R is cyclopropylmethyl or cyclobutylmethyl; R'' and R'''' are the same or different, and are straight or branched chain hydrocarbons of 1 to 5 carbon atoms; X is OH, OR'''''' or

WHEREIN R'''''' is a straight or branched chain, saturated or unsaturated hydrocarbon of 1 to 11 carbon atoms; R4 and R5 are the same or different, and are hydrogen, straight or branched chain, saturated hydrocarbon of 1 to 4 carbon atoms, or R4 and R5 together with the nitrogen atom form a 5or 6-membered heterocyclic ring which may have oxygen as a second heteroatom; and A is a bivalent, straight or branched chain, saturated or unsaturated hydrocarbon of 1 to 10 carbon atoms or said hydrocarbon substituted by 1 or more phenyl moieties, or 1 or more phenyl moieties substituted by alkyl, alkoxy, halogen, nitro or acylamino, and PHARMACEUTICALLY ACCEPTABLE NON-TOXIC SALTS THEREOF ARE USEFUL AS ANALGESICS.

Abstract translation: Benzomorphans的配方：

公开(公告)号：US3441608A

公开(公告)日：1969-04-29

申请号：US3441608D

申请日：1965-11-24

Applicant: BAYER AG

Inventor： SCHUTZ SIEGISMUND ,  HOFFMEISTER FRIEDRICH

IPC: C07C131/08 ,  C07C131/00

公开(公告)号：US3431257A

公开(公告)日：1969-03-04

申请号：US3431257D

申请日：1966-09-06

Applicant: BAYER AG

Inventor： AICHINGER GERD ,  SCHUTZ SIEGISMUND ,  HOFFMEISTER FRIEDRICH

IPC: A61K31/55 ,  C07D223/20 ,  C07D53/04 ,  A61K27/00 ,  C07D53/06

CPC classification number: C07D223/20 ,  A61K31/55