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1.发明授权Optically active pyridine derivatives in pharmaceutical compositions and their use as analgesics and stimulants 失效药物组合物中的光学活性吡啶衍生物及其作为药物和刺激物的用途
公开(公告)号：US3594477A
公开(公告)日：1971-07-20
申请号：US3594477D
申请日：1969-01-14
Applicant: BAYER AG
IPC: A61K31/44 , C07D401/12 , A61K27/00
CPC classification number: C07D401/12 , A61K31/44
Abstract: DEXTRO-ROTATORY AND LEVO-ROTATORY ISOMERS OF N-ACYL-N(2''-PYRIDYL)-1-PIPERIDINO-2-AMINOPROPANES OF THE FORMULA:
2-(PIPERIDINO-CH2-CH(-CH3)-N(-CO-R)-)PYRIDINE
WHEREIN R IS METHYL OR ETHYL OR A PHARMACEUTICALLY ACCEPTABLE NON-TOXIC ACID SALT THEREOF EXHIBIT PHARMACEUTICAL PROPERTIES WHICH DIFFER QUALITATIVELY FROM THE RACEMATE. THE L-ISOMER EXHIBITS APPROXIMATELY THE SAME ANALGESIC ACTIVITY AS THE RACEMATE BUT ALSO EXHIBITS A STRONG SEDATIVE EFFECT. THE D-ISOMER EXHIBITS APPROXIMATELY THE SAME ANALGESIC ACTIVITY AS THE RACEMATE BUT EXHIBITS ALSO A CENTRAL NERVOUS SYSTEM STIMULANT EFFECT.
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