There is provided O-polyalkoxylated high molecular weight nalkanone and n-alkanal oximes corresponding to the formula: BY CONTACTING AN N-PARAFFIN OXIME WITH A BASE, AND THEREAFTER REACTING THE OXIME WITH AN OXIRANE IN THE SUBSTANTIAL ABSENCE OF WATER. The high molecular weight n-alkanone and n-alkanal oximes provided herein are useful as nonionic surfactants, as biodegradable detergents, as chemical intermediates in the production of anionic detergents, as lubricating oil additives, and as anti-rust and anti-icing additives in fuels.