发明授权
- 专利标题： Nitroimidazolyl-triazolo-pyridazine compounds
- 专利标题（中）： 硝基咪唑基 - 三唑并 - 哒嗪化合物
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申请号： US33609973申请日： 1973-02-26
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公开(公告)号： US3928349A公开(公告)日： 1975-12-23
- 发明人: BERGER HERBERT , GALL RUDI , STACH KURT , VOMEL WOLFGANG , HOFFMANN RITA
- 申请人： BOEHRINGER MANNHEIM GMBH
- 专利权人： Boehringer Mannheim Gmbh
- 当前专利权人： Boehringer Mannheim Gmbh
- 优先权： DE2215999 1972-04-01
- 主分类号： A61K31/50
- IPC分类号： A61K31/50 ; A61P31/04 ; C07D403/04 ; C07D487/04 ; C07D237/00
摘要：
Nitroimidazolyl-s-triazolo(4,3-b)pyridazines of the formula:
wherein R1 and R2 are, individually, hydrogen or a numbe organic radicals or, taken together, can be an alkylene bridge; AND R3 is hydrogen or lower alkyl; or, together with R2, R3 can form an alkylene bridge; N IS 0 OR 1; AND THE PHARMACEUTICALLY COMPATIBLE THEREOF, POSSESS HIGH IN VIVO EFFECTIVENESS AS ANTIMICROBIALS.
WHEREIN R is hydrogen or lower alkyl optionally substituted in the 2position by hydroxyl or by lower acyloxy or lower alkoxy; A is hydrogen, halogen, azido, cyano; lower alkyl, alkoxy, alkylthio, alkylsulfonyl, carboxyl; lower alkoxycarbonyl, lower alkoxycarbonimidoyl; or hydrazino, carbamoyl, amidino or a carboximidohydrazide group optionally substituted by one or two lower acyl, alkyl or cycloalkyl radicals; or A is a radical of the formula:
wherein R1 and R2 are, individually, hydrogen or a numbe organic radicals or, taken together, can be an alkylene bridge; AND R3 is hydrogen or lower alkyl; or, together with R2, R3 can form an alkylene bridge; N IS 0 OR 1; AND THE PHARMACEUTICALLY COMPATIBLE THEREOF, POSSESS HIGH IN VIVO EFFECTIVENESS AS ANTIMICROBIALS.
WHEREIN R is hydrogen or lower alkyl optionally substituted in the 2position by hydroxyl or by lower acyloxy or lower alkoxy; A is hydrogen, halogen, azido, cyano; lower alkyl, alkoxy, alkylthio, alkylsulfonyl, carboxyl; lower alkoxycarbonyl, lower alkoxycarbonimidoyl; or hydrazino, carbamoyl, amidino or a carboximidohydrazide group optionally substituted by one or two lower acyl, alkyl or cycloalkyl radicals; or A is a radical of the formula:
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