发明授权
- 专利标题: Diamine-benzophenones and a process for the preparation thereof
- 专利标题(中): 二胺 - 二苯甲酮及其制备方法
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申请号: US485744申请日: 1974-07-03
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公开(公告)号: US3989701A公开(公告)日: 1976-11-02
- 发明人: Edit Toth , Jozsef Torley , Eva Palosi , Szaboles Szeberenyi , Laszlo Szporny , Sandor Gorog , Csilla Meszaros
- 申请人: Edit Toth , Jozsef Torley , Eva Palosi , Szaboles Szeberenyi , Laszlo Szporny , Sandor Gorog , Csilla Meszaros
- 申请人地址: HU Budapest
- 专利权人: Richter Gedeon Vegyeszeti Gyar Rt.
- 当前专利权人: Richter Gedeon Vegyeszeti Gyar Rt.
- 当前专利权人地址: HU Budapest
- 优先权: HURI518 19730726
- 主分类号: C07D295/10
- IPC分类号: C07D295/10 ; A61K31/135 ; A61K31/165 ; A61K31/44 ; A61K31/445 ; A61K31/535 ; A61K31/5375 ; A61K31/55 ; A61P25/24 ; A61P25/26 ; C07C67/00 ; C07C213/00 ; C07C225/22 ; C07C231/00 ; C07C231/02 ; C07C233/43 ; C07D207/06 ; C07D233/56 ; C07D233/61 ; C07D295/135 ; C07D295/00
摘要:
New compounds of the general formula (I) ##SPC1##whereinR.sub.1 and R.sub.2 each is a saturated or unsaturated, straight-chained or branched alkyl group, an aralkyl group, a saturated or unsaturated cycloalkyl group or an aryl group, orR.sub.1 and R.sub.2 together with the adjacent nitrogen atom may form substituted or unsubstituted heterocyclic group with or without a further oxygen or nitrogen heteroatom, andR.sub.3 is hydrogen or an acyl group derived from a C.sub.1.sub.-18 carboxylic acid.The compounds are prepared by reducing the corresponding nitro compounds of the general formula (II) ##SPC2##and optionally acylating the obtained product.The compounds of the general formula (I) and their acid addition salts and quaternary ammonium salts are active primarily in the induction of liver microsomal enzyme, but they also possess valuable antipyretic activity and a yohimbine lethality increasing effect characteristic of antidepressants.
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