发明授权
- 专利标题： Method of producing vaccines
- 专利标题（中）： 生产疫苗的方法
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申请号： US719692申请日： 1976-09-02
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公开(公告)号： US4071619A公开(公告)日： 1978-01-31
- 发明人: Tamaz Vladimirovich Peradze , Eidlya Abramovna Fridman , Nina Vsevolodovna Zheleznova , Vsevolod Mikhailovich Kolikov , Semen Khaimovich-Efimovich Bresler , Boris Viktorovich Mchedlishvili , Viktor Mikhailovich Molodkin , Ljudmila Mikhailovna Molodkina , Nina Vasilievna Katushkina
- 申请人： Tamaz Vladimirovich Peradze , Eidlya Abramovna Fridman , Nina Vsevolodovna Zheleznova , Vsevolod Mikhailovich Kolikov , Semen Khaimovich-Efimovich Bresler , Boris Viktorovich Mchedlishvili , Viktor Mikhailovich Molodkin , Ljudmila Mikhailovna Molodkina , Nina Vasilievna Katushkina
- 专利权人： Tamaz Vladimirovich Peradze,Eidlya Abramovna Fridman,Nina Vsevolodovna Zheleznova,Vsevolod Mikhailovich Kolikov,Bresler Semen Khaimovich Efimo,Mchedlishvili Boris Viktorovic,Viktor Mikhailovich Molodkin,Ljudmila Mikhailovna Molodkina,Nina Vasilievna Katushkina
- 当前专利权人： Tamaz Vladimirovich Peradze,Eidlya Abramovna Fridman,Nina Vsevolodovna Zheleznova,Vsevolod Mikhailovich Kolikov,Bresler Semen Khaimovich Efimo,Mchedlishvili Boris Viktorovic,Viktor Mikhailovich Molodkin,Ljudmila Mikhailovna Molodkina,Nina Vasilievna Katushkina
- 优先权： SU1967101 19731116
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; A61K39/13 ; A61K39/145 ; A61K39/205 ; A61K41/00 ; C12K7/00
摘要：
A method for producing vaccines wherein a suspension of the viral culture is purified by gel chromatography in a column packed with a porous virion non-sorbing silicate material having pore diameter of 50 to 10000 A, followed by adsorption-elution concentration and completion of the vaccine, or the starting suspension of the viral culture is concentrated by adsorption-elution and then purified by gel chromatography in a column packed with porous silicate material having pore diameter of 50 to 10000 A, or the starting suspension of the viral culture is subjected to gel chromatography in a column filled with a porous silicate material having pore diameter of 50 to 10000 A and the final vaccine is produced.