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公开(公告)号:US4071619A
公开(公告)日:1978-01-31
申请号:US719692
申请日:1976-09-02
申请人: Tamaz Vladimirovich Peradze , Eidlya Abramovna Fridman , Nina Vsevolodovna Zheleznova , Vsevolod Mikhailovich Kolikov , Semen Khaimovich-Efimovich Bresler , Boris Viktorovich Mchedlishvili , Viktor Mikhailovich Molodkin , Ljudmila Mikhailovna Molodkina , Nina Vasilievna Katushkina
发明人: Tamaz Vladimirovich Peradze , Eidlya Abramovna Fridman , Nina Vsevolodovna Zheleznova , Vsevolod Mikhailovich Kolikov , Semen Khaimovich-Efimovich Bresler , Boris Viktorovich Mchedlishvili , Viktor Mikhailovich Molodkin , Ljudmila Mikhailovna Molodkina , Nina Vasilievna Katushkina
IPC分类号: A61K39/12 , A61K39/13 , A61K39/145 , A61K39/205 , A61K41/00 , C12K7/00
CPC分类号: A61K39/12 , A61K39/13 , A61K39/145 , A61K39/205 , C12N7/00 , A61K2039/5252 , C12N2760/10034 , C12N2760/10051 , C12N2760/16134 , C12N2760/16151 , C12N2760/20134 , C12N2760/20151
摘要: A method for producing vaccines wherein a suspension of the viral culture is purified by gel chromatography in a column packed with a porous virion non-sorbing silicate material having pore diameter of 50 to 10000 A, followed by adsorption-elution concentration and completion of the vaccine, or the starting suspension of the viral culture is concentrated by adsorption-elution and then purified by gel chromatography in a column packed with porous silicate material having pore diameter of 50 to 10000 A, or the starting suspension of the viral culture is subjected to gel chromatography in a column filled with a porous silicate material having pore diameter of 50 to 10000 A and the final vaccine is produced.
摘要翻译: 一种生产疫苗的方法,其中病毒培养物的悬浮液通过凝胶色谱法在填充有孔径为50至10000A的多孔病毒粒子非吸附硅酸盐材料的柱中进行纯化,然后进行吸附洗脱浓度和疫苗完成 ,或通过吸附洗脱浓缩病毒培养物的起始悬浮液,然后通过凝胶色谱法在填充有孔径为50至10000的多孔硅酸盐材料的柱中纯化,或将病毒培养物的起始悬浮液进行凝胶 在填充有孔径为50至10000的多孔硅酸盐材料的柱中进行色谱法,并制备最终疫苗。