发明授权
US4210663A Halogen substituted benzopyran- and benzothiopyran-4-carboxylic acids
失效
卤素取代的苯并吡喃和苯并噻喃-4-羧酸
- 专利标题: Halogen substituted benzopyran- and benzothiopyran-4-carboxylic acids
- 专利标题(中): 卤素取代的苯并吡喃和苯并噻喃-4-羧酸
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申请号: US959023申请日: 1978-11-08
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公开(公告)号: US4210663A公开(公告)日: 1980-07-01
- 发明人: John L. Belletire
- 申请人: John L. Belletire
- 申请人地址: NY New York
- 专利权人: Pfizer Inc.
- 当前专利权人: Pfizer Inc.
- 当前专利权人地址: NY New York
- 主分类号: A61K31/35
- IPC分类号: A61K31/35 ; A61K31/352 ; A61K31/38 ; A61K31/382 ; A61P3/08 ; A61P3/10 ; A61P25/00 ; A61P27/02 ; A61P27/12 ; C07D311/04 ; C07D311/22 ; C07D311/58 ; C07D311/92 ; C07D335/06 ; C07F7/18
摘要:
Novel halogen-substituted benzopyran-4-carboxylic acids, benzothiopyran-4-carboxylic acids and derivatives thereof useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. Specific compounds disclosed include 6-phenyl-8-chloro-3,4-dihydro-2H-1-benzopyran-4-carboxylic acid, 6,7-dichloro-3,4-dihydrobenzothiopyran-4-carboxylic acid, 6-chloro-8-methyl-3,4-dihydro-2H-1-benzopyran-4-carboxylic acid, 6,8-dichloro-3,4-dihydro-2H-1-benzopyran-4-carboxylic acid, 6-fluoro-3,4-dihydro-2H-1-benzopyran-4-carboxylic acid, 6-chloro-3,4-dihydro-2H-1-benzopyran-4-carboxylic acid, 6-chloro-dihydro-2H-naphtho[1,2-b]pyran-4-carboxylic acid, 6-chloro-3,4-dihydro-2H-1-benzothiopyran-4-carboxylic acid and 6-chloro-3,4-dihydro-2H-1-benzopyran-4-acetic acid. Also disclosed are pharmaceutical compositions containing the novel compounds and a method of using the novel compounds for the treatment of chronic diabetic complications.
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