发明授权
- 专利标题: 1,9-Dihydroxyoctahydrophenanthrenes and intermediates therefor
- 专利标题(中): 1,9-二羟基八氢菲和其中间体
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申请号: US78476申请日: 1979-09-24
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公开(公告)号: US4268523A公开(公告)日: 1981-05-19
- 发明人: Thomas H. Althuis , Charles A. Harbert , Michael R. Johnson , Lawrence S. Melvin, Jr.
- 申请人: Thomas H. Althuis , Charles A. Harbert , Michael R. Johnson , Lawrence S. Melvin, Jr.
- 申请人地址: NY New York
- 专利权人: Pfizer Inc.
- 当前专利权人: Pfizer Inc.
- 当前专利权人地址: NY New York
- 主分类号: C07C41/22
- IPC分类号: C07C41/22 ; C07C41/26 ; C07C43/225 ; C07C43/23 ; C07C45/45 ; C07C45/46 ; C07C45/54 ; C07C45/61 ; C07C45/67 ; C07C45/68 ; C07C45/71 ; C07C45/73 ; C07C49/747 ; C07C49/755 ; C07C49/83 ; C07D211/32 ; C07D213/30 ; C07D213/50 ; C07D317/22 ; C07D317/72 ; A01N35/00 ; C07C49/788
摘要:
Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, benzyl, benzoyl, alkanoyl of 1 to 5 carbon atoms or --CO--(CH.sub.2).sub.p --NR'R" wherein p is 0 or an integer from 1 to 4; each of R' and R" when taken individually is hydrogen or alkyl of 1 to 4 carbon atoms; R' and R" when taken together with the nitrogen to which they are attached form a 5- or 6-membered heterocyclic ring selected from piperidino, pyrollo, pyrrolidino, morpholino and N-alkylpiperazino having from 1 to 4 carbon atoms in the alkyl group;R.sub.2 is selected from hydrogen, alkanoyl of 1 to 6 carbon atoms and benzoyl;R.sub.3 is selected from hydrogen, methyl and ethyl;R.sub.4 is selected from hydrogen, alkyl of 1 to 6 carbon atoms and benzyl;Z is selected from:(a) alkylene having from one to nine carbon atoms;(b) -(alk.sub.1).sub.m -X-(alk.sub.2).sub.n - wherein each of (alk.sub.1) and (alk.sub.2) is alkylene having from 1 to 9 carbon atoms, with the proviso that the summation of carbon atoms in (alk.sub.1) plus (alk.sub.2) is not greater than 9;m and n are each 0 or 1;X is selected from O, S, SO and SO.sub.2 ; andW is selected from hydrogen, methyl, pyridyl, piperidyl, phenyl, monochlorophenyl, monofluorophenyl and ##STR2## wherein W.sub.1 is selected from hydrogen, phenyl, monochlorophenyl and monofluorophenyl; a is an integer from 1 to 5 and b is 0 or an integer from 1 to 4, with the proviso that the sum of a and b is not greater than 5.Compounds I and II are useful as analgesics. Compound III is useful as an intermediate for the preparation of Compounds I and II. Intermediates for the preparation of I, II and III are disclosed. A process for the use of compounds I and II to produce analgesia is also described.
公开/授权文献
- US6077230A Biopsy instrument with removable extractor 公开/授权日:2000-06-20
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