发明授权
US4288437A 2-[(Amino)-aryl-methylene]-benzo[b]thiophen-3(2H)-ones
失效
2 - [(氨基) - 芳基 - 亚甲基] - 苯并[b]噻吩-3(2H) - 酮
- 专利标题: 2-[(Amino)-aryl-methylene]-benzo[b]thiophen-3(2H)-ones
- 专利标题(中): 2 - [(氨基) - 芳基 - 亚甲基] - 苯并[b]噻吩-3(2H) - 酮
-
申请号: US173173申请日: 1980-07-28
-
公开(公告)号: US4288437A公开(公告)日: 1981-09-08
- 发明人: Wolfhard Engel , Gunter Trummlitz , Ernst Seeger , Joachim Kahling
- 申请人: Wolfhard Engel , Gunter Trummlitz , Ernst Seeger , Joachim Kahling
- 申请人地址: DEX Ingelheim am Rhein
- 专利权人: Boehringer Ingelheim GmbH
- 当前专利权人: Boehringer Ingelheim GmbH
- 当前专利权人地址: DEX Ingelheim am Rhein
- 优先权: DEX2931010 19790731
- 主分类号: A61K31/38
- IPC分类号: A61K31/38 ; A61K31/381 ; A61K31/44 ; A61K31/4433 ; A61K31/445 ; A61K31/495 ; A61K31/535 ; A61P25/08 ; C07D333/62 ; C07D333/64 ; C07D409/06
摘要:
Compounds of the formula ##STR1## wherein Ar is phenyl; mono- or di-substituted phenyl, where the substituents are one to two halogens, one to two alkyls of 1 to 3 carbon atoms, or one amino, nitro, cyano or trifluoromethyl; or pyridinyl;R is hydrogen, chlorine, methyl or methoxy;R.sub.1 is hydrogen or methyl;R.sub.2 is hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, methyl-(cycloalkyl of 3 to 8 carbon atoms) or --A--R.sub.4,where A is alkylene of 2 to 3 carbon atoms, and R.sub.4 is hydroxyl, methylamino, dimethylamino, N-methyl-ethylamino, diethylamino, pyrrolidino, piperidino, hexamethyleneimino, morpholino or 4-methyl-1-piperazinyl; orR.sub.1 and R.sub.2, together with each other and the nitrogen atom to which they are attached, form a 4- to 7-membered, saturated or mono-unsaturated, unsubstituted or substituted heterocycle which may contain nitrogen, oxygen, sulfur, sulfinyl or sulfonyl as additional ring members, where the substituents are alkyls of 1 to 3 carbon atoms.The compounds are useful as anticonvulsants.
信息查询