发明授权
US4288452A 1-Aryloxy-3-nitratoalkylamino-2-propanols and use as .beta.-receptor
blocker
失效
1-芳氧基-3-硝基烷基氨基-2-丙醇,用作β受体阻滞剂
- 专利标题: 1-Aryloxy-3-nitratoalkylamino-2-propanols and use as .beta.-receptor blocker
- 专利标题(中): 1-芳氧基-3-硝基烷基氨基-2-丙醇,用作β受体阻滞剂
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申请号: US10781申请日: 1979-02-09
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公开(公告)号: US4288452A公开(公告)日: 1981-09-08
- 发明人: Johannes Sombroek , Karl-Heinz Becker , Klaus O. Minck , Hans-Joachim Enenkel
- 申请人: Johannes Sombroek , Karl-Heinz Becker , Klaus O. Minck , Hans-Joachim Enenkel
- 申请人地址: DEX Darmstadt
- 专利权人: Merck Patent Gesellschaft mit beschrankter Haftung
- 当前专利权人: Merck Patent Gesellschaft mit beschrankter Haftung
- 当前专利权人地址: DEX Darmstadt
- 优先权: DEX2805404 19780209
- 主分类号: A61K31/13
- IPC分类号: A61K31/13 ; A61K31/135 ; A61K31/165 ; A61K31/40 ; A61K31/403 ; A61K31/404 ; A61K31/47 ; A61P25/02 ; C07C67/00 ; C07C213/00 ; C07C217/30 ; C07C217/32 ; C07C231/00 ; C07C231/12 ; C07C233/25 ; C07C253/00 ; C07C255/54 ; C07C313/00 ; C07C319/20 ; C07C323/11 ; C07D209/08 ; C07D209/30 ; C07D209/32 ; C07D209/88 ; C07D215/20 ; A61K31/21 ; A61K31/275 ; C07C77/02
摘要:
Compounds of the formulaAr--O--CH.sub.2 --CHOH--CH.sub.2 --NH--RwhereinAr is phenyl; phenyl monosubstituted or polysubstituted by halogen, cyano, acylamino (in which the acyl group has 1-7 carbon atoms), alkanoyl of 1-4 carbon atoms, alkyl (in which the chain can be interrupted by 1 or 2 oxygen atoms or by one sulfur atom and/or in which a multiple bond can be present) of a total of 1-10 carbon atoms, cycloalkyl of 3-8 carbon atoms, and/or cycloalkoxy of 3-8 carbon atoms; naphthyl; indanyl; indenyl; tetralyl; indolyl; indolyl monosubstituted or polysubstituted by alkyl, each of 1-4 carbon atoms; carbazolyl; or 1,2,3,4-tetrahydro-2-oxoquinolyl; andR is nitratoalkyl of 2-10 carbon atoms,and the physiologically acceptable acid addition salts thereof have valuable pharmacological properties, e.g., which make them useful for prophylaxis and treatment of heart problems, e.g., as .beta.-receptor blockers.
公开/授权文献
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