发明授权
US4289774A Lipid lowering and anti-thrombotic 6-arylpyridazin-3-ones and a process
for their preparation
失效
降脂和抗血栓形成6-芳基哒嗪-3-酮及其制备方法
- 专利标题： Lipid lowering and anti-thrombotic 6-arylpyridazin-3-ones and a process for their preparation
- 专利标题（中）： 降脂和抗血栓形成6-芳基哒嗪-3-酮及其制备方法
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申请号： US86604申请日： 1979-10-19
-
公开(公告)号： US4289774A公开(公告)日： 1981-09-15
- 发明人: Erich Schacht , Hans-Adolf Kurmeier , Joachim Gante , Reinhard Lissner , Guido Melzer , Dieter Orth
- 申请人： Erich Schacht , Hans-Adolf Kurmeier , Joachim Gante , Reinhard Lissner , Guido Melzer , Dieter Orth
- 申请人地址： DEX Darmstadt
- 专利权人： Merck Patent Gesellschaft mit beschrankter Haftung
- 当前专利权人： Merck Patent Gesellschaft mit beschrankter Haftung
- 当前专利权人地址： DEX Darmstadt
- 优先权： DEX2845456 19781019
- 主分类号： A61K31/50
- IPC分类号： A61K31/50 ; A61P3/06 ; A61P3/08 ; A61P7/02 ; A61P9/10 ; A61P25/00 ; A61P25/04 ; A61P29/00 ; C07D237/04 ; C07D237/14 ; C07D237/32 ; C07D401/04 ; C07D237/26
摘要：
Compounds of the formula ##STR1## wherein R.sup.1 is 4-biphenylyl, 4-phenoxyphenyl or 4-biphenylyl or 4-phenoxyphenyl substituted in the 4'-position by F, Cl, Br or I; R.sup.2 is H, C.sub.1-4 -alkyl, hydroxy-C.sub.1-4 -alkyl or pyridyl; R.sup.3 and R.sup.6 are each H or alkyl of 1-4 carbon atoms, or together are--(CH.sub.2).sub.4 --; and R.sup.4 and R.sup.5 are each H or together are a C--C bond; at least one of the radicals R.sup.2, R.sup.3 and R.sup.6 being other than hydrogen, possess valuable pharmacological properties, e.g., lower lipid levels and are anti-thrombotic.
公开/授权文献
- USD410065S Faucet 公开/授权日：1999-05-18
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