发明授权
US4416985A Process for preparing 3.beta.,7.beta.-dihydroxy-.DELTA..sup.5 -steroids
失效
制备3β，7β-二羟基-DTATA 5-类固醇的方法
- 专利标题： Process for preparing 3.beta.,7.beta.-dihydroxy-.DELTA..sup.5 -steroids
- 专利标题（中）： 制备3β，7β-二羟基-DTATA 5-类固醇的方法
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申请号： US317822申请日： 1981-11-03
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公开(公告)号： US4416985A公开(公告)日： 1983-11-22
- 发明人: Karl Petzoldt , Rudolf Wiechert , Henry Laurent , Klaus Nickisch , Dieter Bittler
- 申请人： Karl Petzoldt , Rudolf Wiechert , Henry Laurent , Klaus Nickisch , Dieter Bittler
- 申请人地址： DEX Berlin and Bergkamen
- 专利权人： Schering, Aktiengesellschaft
- 当前专利权人： Schering, Aktiengesellschaft
- 当前专利权人地址： DEX Berlin and Bergkamen
- 优先权： DEX3042136 19801103
- 主分类号： C07J21/00
- IPC分类号： C07J21/00 ; C07J53/00 ; C07J71/00 ; C12P33/06 ; C12P33/20 ; C12R1/645 ; C07J7/00
摘要：
A process for preparing a 3.beta.,7.beta.-dihydroxy-.DELTA..sup.5 steroid of the formula ##STR1## wherein Q is ##STR2## and R.sub.1 is hydrogen, trimethylacetyl, tert-butyldimethylsilyl, dimethyl-2-(3-methylbutyl)silyl or tribenzylsilyl,comprises fermenting a 3.beta.-hydroxy-.DELTA..sup.5 -steroid of the formula ##STR3## wherein Q is as defined above, andR.sub.2 is hydrogen or alkanoyl of 2-6 carbon atoms,with a culture of Botryodiplodia malorum to obtain the corresponding 3.beta.,7.beta.-dihydroxy-.DELTA..sup.5 -steroid; and, optionally, reacting the resultant product with trimethylacetic anhydride, tert-butyldimethylsilyl chloride, dimethyl-2-(3-methylbutyl)silyl chloride, or tribenzylsilyl chloride.
公开/授权文献
- US6026601A Ironing board adapted to vertical surface 公开/授权日：2000-02-22