发明授权
- 专利标题： Anthracyclinone trisaccharide compounds
- 专利标题（中）： 蒽环类三糖化合物
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申请号： US370212申请日： 1982-04-20
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公开(公告)号： US4418192A公开(公告)日： 1983-11-29
- 发明人: Hiroshi Tanaka , Takeo Yoshioka , Yasutaka Shimauchi , Toshikazu Oki , Tomoyuki Ishikura , Tomio Takeuchi , Hamao Umezawa
- 申请人： Hiroshi Tanaka , Takeo Yoshioka , Yasutaka Shimauchi , Toshikazu Oki , Tomoyuki Ishikura , Tomio Takeuchi , Hamao Umezawa
- 申请人地址： JPX Tokyo
- 专利权人： Sanraku-Ocean Co., Ltd.
- 当前专利权人： Sanraku-Ocean Co., Ltd.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX56-61766 19810423
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; A61K31/7028 ; A61K31/7034 ; A61K31/704 ; A61P35/00 ; C07H15/252 ; A61K31/71 ; C07H15/24
摘要：
Disclosed are novel anthracyclinone glycosides represented by the chemical formula ##STR1## wherein R.sup.1 is hydrogen or methyl;R.sup.2 is hydrogen or hydroxyl;R.sup.3 is hydrogen or methoxycarbonyl;R.sup.4 is two hydrogen atoms or an oxygen atom;R.sup.5 is hydrogen, hydroxyl or --OCOX (wherein X is lower alkyl or aralkyl);R.sup.6 is amino, monomethylamino or dimethylamino;R.sup.7 is hydrogen or acetyl; andR.sup.8 is hydrogen or L-cinerulose A ##STR2## but, when R.sup.1 and R.sup.3 are hydrogen and methoxycarbonyl respectively, R.sup.2 is hydrogen; R.sup.4 is two hydrogen atoms; R.sup.5 is hydrogen; R.sup.6 is amino, monoethylamino or dimethylamino; R.sup.7 is acetyl; and R.sup.8 is L-cinerulose A,and their acid addition salts and a method for preparation thereof which consists of treating O-alpha-L-cinerulosyl-(1.fwdarw.4)-O-(3-O-acetyl-2-deoxy-alpha-L-fucosyl)-(1.fwdarw.4)-alpha-L-rhodosamine with corresponding aglycones.
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