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206 条记录 (耗时 0.026 秒)

    Anthracyclinone trisaccharide compounds
    1.
    发明授权
    Anthracyclinone trisaccharide compounds 失效
    蒽环类三糖化合物

    公开(公告)号：US4418192A

    公开(公告)日：1983-11-29

    申请号：US370212

    申请日：1982-04-20

    申请人： Hiroshi Tanaka ,  Takeo Yoshioka ,  Yasutaka Shimauchi ,  Toshikazu Oki ,  Tomoyuki Ishikura ,  Tomio Takeuchi ,  Hamao Umezawa

    发明人： Hiroshi Tanaka ,  Takeo Yoshioka ,  Yasutaka Shimauchi ,  Toshikazu Oki ,  Tomoyuki Ishikura ,  Tomio Takeuchi ,  Hamao Umezawa

    IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07H15/252 ,  A61K31/71 ,  C07H15/24

    CPC分类号： C07H15/252

    摘要： Disclosed are novel anthracyclinone glycosides represented by the chemical formula ##STR1## wherein R.sup.1 is hydrogen or methyl;R.sup.2 is hydrogen or hydroxyl;R.sup.3 is hydrogen or methoxycarbonyl;R.sup.4 is two hydrogen atoms or an oxygen atom;R.sup.5 is hydrogen, hydroxyl or --OCOX (wherein X is lower alkyl or aralkyl);R.sup.6 is amino, monomethylamino or dimethylamino;R.sup.7 is hydrogen or acetyl; andR.sup.8 is hydrogen or L-cinerulose A ##STR2## but, when R.sup.1 and R.sup.3 are hydrogen and methoxycarbonyl respectively, R.sup.2 is hydrogen; R.sup.4 is two hydrogen atoms; R.sup.5 is hydrogen; R.sup.6 is amino, monoethylamino or dimethylamino; R.sup.7 is acetyl; and R.sup.8 is L-cinerulose A,and their acid addition salts and a method for preparation thereof which consists of treating O-alpha-L-cinerulosyl-(1.fwdarw.4)-O-(3-O-acetyl-2-deoxy-alpha-L-fucosyl)-(1.fwdarw.4)-alpha-L-rhodosamine with corresponding aglycones.

    摘要翻译： 公开了由化学式（IMAGE）（I）表示的新型蒽环酸苷，其中R1是氢或甲基; R2是氢或羟基; R3是氢或甲氧基羰基; R4是两个氢原子或氧原子; R5是氢，羟基或-OCOX（其中X是低级烷基或芳烷基）; R6是氨基，单甲基氨基或二甲基氨基; R7是氢或乙酰基; 并且R 8是氢或L-果糖醛酸A，但是当R 1和R 3分别是氢和甲氧基羰基时，R 2是氢; R4是两个氢原子; R5是氢; R6是氨基，单乙基氨基或二甲基氨基; R7是乙酰基; R8为L-丝瓜糖苷A及其酸加成盐及其制备方法，其由O-α-L-脯氨酰基 - （1-> 4）-O-（3-O-乙酰基-2-脱氧 α-L-岩藻糖基） - （1→4）-alpha-L-罗丹明与相应的糖苷配基。

    Tylosin derivatives
    2.
    发明授权
    Tylosin derivatives 失效
    泰乐菌素衍生物

    公开(公告)号：US4612372A

    公开(公告)日：1986-09-16

    申请号：US754568

    申请日：1985-07-12

    申请人： Takeo Yoshioka ,  Miharu Maeda ,  Rokuro Okamoto ,  Yasutaka Shimauchi ,  Tomoyuki Ishikura ,  Tsutomu Sawa ,  Tomio Takeuchi ,  Hamao Umezawa

    发明人： Takeo Yoshioka ,  Miharu Maeda ,  Rokuro Okamoto ,  Yasutaka Shimauchi ,  Tomoyuki Ishikura ,  Tsutomu Sawa ,  Tomio Takeuchi ,  Hamao Umezawa

    IPC分类号： C07H17/08

    CPC分类号： C07H17/08

    摘要： Novel tylosin derivatives are represented by formula: ##STR1## wherein R represents a hydrogen atom, an acetyl group or a propionyl group; X represents a group --CO-- or --SO.sub.2 --; Y represents a fluorine atom, an acetyl group, a methanesulfonyl group, a methylthio group, a benzoyl group or a methoxy group bound to the benzyl group at the 2-position or 4-position; and Z represents a hydrogen atom or a D-mycinose residue: ##STR2## The tylosin derivatives which are antibiotics of macrolide type provide improved antibacterial activity and improved ability of absorption and excretion in vivo.

    摘要翻译： 新型泰乐菌素衍生物由下式表示：其中R代表氢原子，乙酰基或丙酰基; X表示-CO-或-SO 2 - 基团; Y表示在2位或4位与苄基结合的氟原子，乙酰基，甲磺酰基，甲硫基，苯甲酰基或甲氧基; Z代表氢原子或D-霉菌素残留物：作为大环内酯类抗生素的泰乐菌素衍生物提供了改善的抗菌活性和提高体内吸收和排泄的能力。

    Antibiotics aclacinomycins A and B
    6.
    发明授权
    Antibiotics aclacinomycins A and B 失效
    抗生素阿卡霉素A和B

    公开(公告)号：US3988315A

    公开(公告)日：1976-10-26

    申请号：US596682

    申请日：1975-07-16

    申请人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Akira Takamatsu ,  Toshikazu Oki

    发明人： Hamao Umezawa ,  Tomio Takeuchi ,  Masa Hamada ,  Akira Takamatsu ,  Toshikazu Oki

    IPC分类号： C07H15/252 ,  C12P1/06 ,  C12P19/56 ,  C07H17/08

    CPC分类号： C07H15/252 ,  Y10S435/886

    摘要： New antitumor agents named aclacinomycins A and B, which are anthracycline glycosides and inhibit the growth of various microorganisms e.g., Staphylococcus aureus, Micrococcus flavus, Corynebacterium bovis and inhibit the growth of animal tumors such as leukemia L1210 and P388 and lymphoma 6C3HED in mice and hepatomas in rats are produced by the fermentation of a microorganism belonging to the genus Streptomyces which has been designated Streptomyces galilaeus (MA144-M1 and A.T.C.C. 31133); they are recovered from the broth by conventional methods for recovering antibiotics.

    摘要翻译： 新型抗肿瘤剂名为阿沙利霉素A和B，它们是蒽环类苷并抑制各种微生物的生长，例如金黄色葡萄球菌，黄曲霉，牛磺酸棒状杆菌，并抑制小鼠和肝癌中白血病L1210和P388和淋巴瘤6C3HED等动物肿瘤的生长 在大鼠中通过发酵属于链霉菌属（Streptomyces）的微生物来产生，其被命名为马链霉菌（Streptomyces galilaeus）（MA144-M1和ATCC 31133）; 它们通过用于回收抗生素的常规方法从肉汤中回收。