发明授权
- 专利标题: Bromhexine delayed-release pharmaceutical form
- 专利标题(中): 溴马酸缓释药物形式
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申请号: US393760申请日: 1982-06-30
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公开(公告)号: US4438091A公开(公告)日: 1984-03-20
- 发明人: Peter Gruber , Jochen Schmid , Horst Lechner , Eckhart Bauer
- 申请人: Peter Gruber , Jochen Schmid , Horst Lechner , Eckhart Bauer
- 申请人地址: DEX Biberach an der Riss
- 专利权人: Dr. Karl Thomae GmbH
- 当前专利权人: Dr. Karl Thomae GmbH
- 当前专利权人地址: DEX Biberach an der Riss
- 优先权: DEX3126703 19810707
- 主分类号: A61K9/22
- IPC分类号: A61K9/22 ; A61K9/20 ; A61K9/28 ; A61K9/32 ; A61K9/50 ; A61K9/52 ; A61K31/135 ; A61P11/10 ; A61K9/24
摘要:
This invention relates to vehicles for the administration of bromhexine. More specifically, this invention relates to a composition for the delayed release of bromhexine which comprises (i) spheroid particles or tablets comprised of (a) bromhexine and/or acid addition salts thereof and (b) at least one pharmacologically acceptable acid or acidic substance, the total amount of acid substance from acid addition salts present and the acid or acidic substance being in a ratio of at least 2 mols to 1 mol of bromhexine, and (ii) a coating surrounding said spheroid particles or tablets, said coating being comprised of from about 50 to 100 percent by weight of acid-insoluble lacquers soluble in intestinal juices and from about 0 to 50 percent by weight of lacquers insoluble in gastric and intestinal juices and said coating being present in an amount of from about 2 to 30 percent by weight, based upon the weight of the spheroid particles or tablets.
公开/授权文献
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