发明授权
- 专利标题: Aminoglycosides and use thereof
- 专利标题(中): 氨基糖苷类及其用途
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申请号: US402812申请日: 1982-07-28
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公开(公告)号: US4438107A公开(公告)日: 1984-03-20
- 发明人: Isamu Watanabe , Takashi Yamaguchi , Kazuhiro Kamiya , Toshihito Mori , Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya
- 申请人: Isamu Watanabe , Takashi Yamaguchi , Kazuhiro Kamiya , Toshihito Mori , Hamao Umezawa , Sumio Umezawa , Tsutomu Tsuchiya
- 申请人地址: JPX Aichi JPX Tokyo
- 专利权人: Kowa Company, Ltd.,Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
- 当前专利权人: Kowa Company, Ltd.,Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
- 当前专利权人地址: JPX Aichi JPX Tokyo
- 优先权: JPX56-117856 19810729
- 主分类号: A61K31/70
- IPC分类号: A61K31/70 ; A61K31/7028 ; A61K31/7034 ; A61K31/7036 ; A61P31/04 ; C07D303/16 ; C07H15/224 ; C07H15/226 ; C08B37/00
摘要:
An aminoglycoside compound of the following formula ##STR1## wherein one of R.sub.1 and R.sub.2 represents a hydrogen atom and the other, a methyl group, R.sub.3 represents a hydrogen atom or an amino acyl group having 2 to 5 carbon atoms, R.sub.4 represents a lower alkyl group substituted by one or two substituents selected from the class consisting of hydroxy and amino groups, or a hexopyranosyl group whose hydroxy groups may be substituted by amino groups,and a pharmaceutically acceptable acid addition salt thereof; and an antibiotic composition comprising said compound and its pharmaceutically acceptable acid addition salt.