发明授权
US4530923A N-acetamilide, N-(phenoxy-2-propanol)- and
N-(phenylamino-2-propanol)-cyclicamines
失效
N-乙酰苯胺,N-(苯氧基-2-丙醇)和N-(苯基氨基-2-丙醇) - 环胺
- 专利标题: N-acetamilide, N-(phenoxy-2-propanol)- and N-(phenylamino-2-propanol)-cyclicamines
- 专利标题(中): N-乙酰苯胺,N-(苯氧基-2-丙醇)和N-(苯基氨基-2-丙醇) - 环胺
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申请号: US435493申请日: 1982-10-20
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公开(公告)号: US4530923A公开(公告)日: 1985-07-23
- 发明人: Jozsef Rakoczi , Edit Berenyi nee Poldermann , Bela Fekete , Laszlo Szekeres , Gyula Papp , Eva Keszthelyi nee Udvary
- 申请人: Jozsef Rakoczi , Edit Berenyi nee Poldermann , Bela Fekete , Laszlo Szekeres , Gyula Papp , Eva Keszthelyi nee Udvary
- 申请人地址: HUX Budapest
- 专利权人: Egyt Gyogyszervegyeszeti Gyar
- 当前专利权人: Egyt Gyogyszervegyeszeti Gyar
- 当前专利权人地址: HUX Budapest
- 优先权: HUX3308/81 19810611
- 主分类号: C07D295/08
- IPC分类号: C07D295/08 ; A61K31/395 ; A61K31/55 ; A61P9/06 ; C07D295/088 ; C07D295/092 ; C07D295/10 ; C07D295/13 ; C07D295/15 ; C07D223/02 ; A61K31/33
摘要:
The invention relates to new cyclic imines of the general formula (I), ##STR1## wherein A represents carbonyl or hydroxymethylene,B is oxygen or imino,R stands for hydrogen or lower alkyl,X.sub.1 and X.sub.2 may be the same or different and represent hydrogen, halogen, lower alkyl or alkoxy, amino or nitro,n is 6 or 7, andm is 0 or 1,and pharmaceutically acceptable acid addition salts and quaternary salts thereof. The invention relates further to a process for the preparation of said compounds, to pharmaceutical compositions containing said compounds as the active ingredient and to a process for the preparation of said pharmaceutical compositions.The cyclic imine derivatives of the invention possess valuable antiarrhythmic properties and can be used to advantage in the treatment of cardiovascular diseases.
公开/授权文献
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