发明授权
US4543210A Process for producing a high purity antihemophilic factor concentrate
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生产高纯度抗血友病因子浓缩物的方法
- 专利标题: Process for producing a high purity antihemophilic factor concentrate
- 专利标题(中): 生产高纯度抗血友病因子浓缩物的方法
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申请号: US658081申请日: 1984-10-04
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公开(公告)号: US4543210A公开(公告)日: 1985-09-24
- 发明人: Gautam Mitra , Paul K. Ng
- 申请人: Gautam Mitra , Paul K. Ng
- 申请人地址: IN Elkhart
- 专利权人: Miles Laboratories, Inc.
- 当前专利权人: Miles Laboratories, Inc.
- 当前专利权人地址: IN Elkhart
- 主分类号: C07K14/745
- IPC分类号: C07K14/745 ; A61K35/14 ; A61K35/16 ; A61K38/00 ; A61K38/16 ; A61K38/43 ; C07K14/435 ; C07K14/755 ; A23J1/06
摘要:
There is disclosed an improved process for producing high purity antihemophilic factor concentrate from an antihemophilic factor-containing dispersion or solution isolated from blood plasma or a blood plasma fraction, wherein the improvement is in carrying-out two consecutive precipitations using a combination of precipitants in each precipitation, first a combination of 1-4% by weight, based on weight of solution, of polyethylene glycol and 0.1-0.2 ml of 1-3%, based on weight of suspension, aluminum hydroxide suspension per gram of protein in the starting dispersion or solution, followed by a combination of added polyethylene glycol to provide a final concentration of 9-13% by weight, based on weight of the resulting solution, and 10-20% by weight of glycine, based on weight of the polyethylene glycol solution, and 10-20% by weight, based on weight of the polyethylene glycol solution, of sodium chloride.
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