发明授权
US4608388A Novel [4,2,0]bicyclooctane derivatives with valuable therapeutic
properties
失效
具有有价值的治疗性质的新型[4,2,0]双环辛烷衍生物
- 专利标题: Novel [4,2,0]bicyclooctane derivatives with valuable therapeutic properties
- 专利标题(中): 具有有价值的治疗性质的新型[4,2,0]双环辛烷衍生物
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申请号: US716872申请日: 1985-03-27
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公开(公告)号: US4608388A公开(公告)日: 1986-08-26
- 发明人: Arthur F. Kluge , Anthony L. Willis , Counde O'Yang
- 申请人: Arthur F. Kluge , Anthony L. Willis , Counde O'Yang
- 申请人地址: CA Palo Alto
- 专利权人: Syntex (U.S.A.) Inc.
- 当前专利权人: Syntex (U.S.A.) Inc.
- 当前专利权人地址: CA Palo Alto
- 主分类号: C07C43/178
- IPC分类号: C07C43/178 ; A61K31/045 ; A61K31/085 ; A61K31/11 ; A61K31/19 ; A61K31/215 ; A61P3/06 ; A61P7/02 ; A61P9/00 ; A61P9/10 ; A61P9/12 ; C07C27/00 ; C07C29/147 ; C07C33/05 ; C07C35/31 ; C07C41/00 ; C07C45/00 ; C07C45/29 ; C07C45/30 ; C07C47/26 ; C07C47/267 ; C07C47/27 ; C07C47/273 ; C07C47/277 ; C07C49/743 ; C07C49/747 ; C07C51/00 ; C07C53/136 ; C07C59/42 ; C07C59/46 ; C07C59/56 ; C07C59/62 ; C07C67/00 ; C07C69/02 ; C07C69/73 ; C07C69/732 ; C07C69/734 ; C07C233/12 ; C07C233/16 ; C07C233/24 ; C07C233/25 ; C07C233/75 ; C07C275/34 ; C07F7/18 ; H04N9/79 ; C07C69/74
摘要:
Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension, and atherosclerosis are compounds depicted in formulas (1), (2), and (3): ##STR1## wherein: n is 2 or 3;R.sub.1 is CH.sub.2 OH, CHO, CO.sub.2 R or CO.sub.2 H;R.sub.2 is hydrogen or methyl; andR.sub.3 is linear or branched alkyl having 5-10 carbon atoms, ##STR2## optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen,in whicha is 0, 1 or 2;b is 3-7;m is 1 or 2; andR is ##STR3## in which each R.sub.4 is independently hydrogen or lower alkyl having 1-6 carbon atoms,and the pharmaceutically acceptable, non-toxic salts and esters thereof.
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