Patent search ipc:"C07C53/136" Page 1

1.

发明公开
TREPROSTINIL DERIVATIVES AND COMPOSITIONS AND USES THEREOF 审中-公开

公开(公告)号：US20240124385A1

公开(公告)日：2024-04-18

申请号：US18516407

申请日：2023-11-21

Applicant: CORSAIR PHARMA, INC.

Inventor： Xiaoming ZHANG , Meenakshi S. VENKATRAMAN , Cyrus K. BECKER

IPC: C07C69/734 , A61K9/70 , C07C53/136 , C07C59/11 , C07C59/13 , C07C69/28 , C07C69/675 , C07C69/68 , C07C69/708 , C07C69/712 , C07C69/74 , C07C69/75 , C07C69/96 , C07D305/08 , C07D307/24 , C07D307/30 , C07D309/08

CPC classification number: C07C69/734 , A61K9/7023 , C07C53/136 , C07C59/11 , C07C59/13 , C07C69/28 , C07C69/675 , C07C69/68 , C07C69/708 , C07C69/712 , C07C69/74 , C07C69/75 , C07C69/96 , C07D305/08 , C07D307/24 , C07D307/30 , C07D309/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/14

Abstract: The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.

2.

发明授权
Treprostinil derivatives and compositions and uses thereof 有权

公开(公告)号：US10246403B2

公开(公告)日：2019-04-02

申请号：US15735546

申请日：2016-06-14

Applicant: CORSAIR PHARMA, INC.

Inventor： Xiaoming Zhang , Meenakshi S. Venkatraman , Cyrus K. Becker

IPC: C07C69/734 , C07C69/74 , C07C53/136 , C07C59/11 , C07C59/13 , A61K9/70 , C07D309/08 , C07C69/28 , C07C69/708 , C07C69/712 , C07D305/08 , C07C69/675 , C07C69/68 , C07C69/75 , C07C69/96 , C07D307/24

Abstract: The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.

3.

发明授权
Treprostinil derivatives and compositions and uses thereof 有权

公开(公告)号：US09643911B2

公开(公告)日：2017-05-09

申请号：US14829180

申请日：2015-08-18

Applicant: CORSAIR PHARMA, INC.

Inventor： Xiaoming Zhang , Meenakshi S. Venkatraman , Cyrus K. Becker

IPC: C07C69/28 , C07C69/68 , C07C69/75 , C07C69/675 , C07C69/96 , C07D309/08 , C07C69/708 , C07C69/712 , C07D305/08 , C07D307/30 , A61K9/70 , C07C59/13 , C07C53/136 , C07C69/74 , C07C59/11

CPC classification number: C07C69/74 , A61K9/7023 , C07C53/136 , C07C59/11 , C07C59/13 , C07C69/28 , C07C69/675 , C07C69/68 , C07C69/708 , C07C69/712 , C07C69/75 , C07C69/96 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/14 , C07D305/08 , C07D307/24 , C07D307/30 , C07D309/08

Abstract: The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.

4.

发明授权
Farnesyl-protein transferase inhibitors 失效

公开(公告)号：US6051565A

公开(公告)日：2000-04-18

申请号：US30300

申请日：1998-02-25

Applicant: Tattym E. Shaikenov , Sergazy M. Adekenov

Inventor： Tattym E. Shaikenov , Sergazy M. Adekenov

IPC: C07D307/93 , A61K31/28 , A61K31/34 , A61K31/343 , A61K31/35 , A61K31/365 , A61K31/475 , A61K31/505 , A61K31/5377 , A61K31/56 , A61K31/66 , A61K31/661 , A61K31/6615 , A61K31/675 , A61K31/70 , A61K33/24 , A61K45/06 , A61P35/00 , A61P43/00 , C07D303/38 , C07D307/935 , C07D493/04 , C07D493/10 , C07D493/14 , C07D493/20 , C07F9/09 , C07F9/117 , C07F9/655 , C07C53/136

CPC classification number: C07D307/935 , A61K31/34 , A61K31/343 , A61K31/365 , A61K31/475 , A61K31/505 , A61K31/5377 , A61K31/66 , A61K31/675 , A61K33/24 , A61K45/06 , C07D303/38 , C07D307/93 , C07D493/04 , C07D493/10 , C07F9/098

Abstract: Substantially pure preparations of phosphosesquiterpenes are described. The compounds inhibit farnesyl-protein transferase activity and are useful for the treatment of cancer. Methods for inhibiting farnesyl-protein transferase activity are also described.

5.

发明授权
Process for producing L-ambrox 失效
Title translation: 生产L-Ambrox的方法

公开(公告)号：US5290955A

公开(公告)日：1994-03-01

申请号：US995978

申请日：1992-12-23

Applicant: Goro Asanuma , Yoshin Tamai

Inventor： Goro Asanuma , Yoshin Tamai

IPC: C07B57/00 , C07C29/147 , C07C29/40 , C07C35/36 , C07C45/62 , C07C51/353 , C07C51/487 , C07C53/136 , C07C57/26 , C07C59/11 , C07D307/92 , C11B9/00

CPC classification number: C07D307/92 , C07B57/00 , C07C29/147 , C07C29/40 , C07C35/36 , C07C403/08 , C07C403/12 , C07C403/20 , C07C45/62 , C07C51/487 , C07C57/26 , C07C59/11 , C11B9/0076 , C07C2101/16

Abstract: (-)-2,5,5,8a-Tetramethyl-1-(carboxymethyl)-2-hydroxydecalin is subjected to lactonization by dehydration to form decahydro-3a,6,6,9a-tetramethyl(3a.alpha.,5a.beta.,9a.alpha.,9b.beta.)-(+)-naphtho[2,1-b]furan-2(1H)-one, which is then reduced with a metal hydride to convert it into (-)-2,5,5,8a-tetramethyl-1-(carboxymethyl)-2-hydroxydecalin, followed by dehydrative cyclization to give L-ambrox.The (-)-2,5,5,8a-tetramethyl-1-(carboxymethyl)-2-hydroxydecalin is produced from its racemic mixture. The resolution is performed using a 1-(aryl)ethylamine. The starting material for the synthesis is beta-ionone.

Abstract translation: （ - ） - 2,5,5,8a-四甲基-1-（羧甲基）-2-羟基环己酮通过脱水进行内酯化，形成十氢-3a，6,6,9a-四甲基（3a（α），5a（ β），9a（α），9b（β）） - （+） - 萘并（2,1-b）呋喃-2（1H） - 酮，然后用金属氢化物还原成（ - ） -2,5,5,8a-四甲基-1-（羧甲基）-2-羟基卡那灵，然后脱水环化得到L-安息香。（ - ） - 2,5,5,8a-四甲基-1-（羧甲基）-2-羟基卡那肽由其外消旋混合物产生。分辨率使用1-（芳基）乙胺进行。合成的起始原料是β-紫罗兰酮。

6.

发明授权
Process for preparation of 1-[1,5-di-(3,3-dimethylnorborn-2-yl)-3-pentyl]-1,5,9-triazanonane and novel intermediates 失效
Title translation: 制备1- {8,5-二（3,3-二甲基降冰片基-2-基）-3-戊基{9-1,5,9-三氮杂壬烷和新中间体的方法

公开(公告)号：US4139559A

公开(公告)日：1979-02-13

申请号：US869879

申请日：1978-01-16

Applicant: Nathaniel Grier , Richard A. Dybas , Robert A. Strelitz

Inventor： Nathaniel Grier , Richard A. Dybas , Robert A. Strelitz

IPC: A01N33/04 , C07C31/137 , C07C49/115 , C07C53/136 , C07C87/40

CPC classification number: A01N33/04 , C07C31/137 , C07C49/115 , C07C53/136

Abstract: A process for preparing 1-[1,5-di-(3,3-dimethylnorborn-2-yl)-3-pentyl]-1,5,9-triazanonane from 1,5-di-(3,3-dimethylnorborn-2-yl)-3-pentanone by reaction with ammonia to form, after reduction, 3-amino-[1,5-di-(3,3-dimethylnorborn-2-yl)pentane]. This latter compound is reacted with acrylonitrile, reduced, and the diamine product again reacted with acrylonitrile and again reduced. Alternative routes wherein the ketone is reduced to the novel alcohol and optionally the novel halide and either then reacted with 3,3'-iminobispropylamine to form the desired polyamine are also shown.

Abstract translation: 从1,5-二（3,3-二甲基牛磺酸）制备1- [1,5-二（3,3-二甲基牛磺-2-基）-3-戊基] -1,5,9-三氮杂壬烷的方法 -2-基）-3-戊酮通过与氨反应，在还原后形成3-氨基 - [1,5-二（3,3-二甲基牛磺酸-2-基）戊烷]。后一种化合物与丙烯腈反应，还原，二胺产物再次与丙烯腈反应并再次还原。还示出了替代途径，其中酮被还原成新的醇和任选的新型卤化物，然后与3,3'-亚氨基双丙胺反应以形成所需的多胺。

7.

发明授权
Treprostinil derivatives and compositions and uses thereof 有权

公开(公告)号：US10988435B2

公开(公告)日：2021-04-27

申请号：US16880146

申请日：2020-05-21

Applicant: CORSAIR PHARMA, INC.

Inventor： Xiaoming Zhang , Meenakshi S. Venkatraman , Cyrus K. Becker

IPC: C07C69/734 , C07C69/74 , C07C53/136 , C07C59/11 , C07C59/13 , A61K9/70 , C07D309/08 , C07C69/708 , C07C69/712 , C07D305/08 , C07C69/675 , C07C69/68 , C07C69/75 , C07C69/96 , C07D307/24 , C07C69/28 , C07D307/30

Abstract: The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.