发明授权
US4789668A 1.alpha.,7.alpha.-dithio-substituted spirolactones, processes for their
preparation, and their use as medicines
失效
1α，7α-二硫代取代的己内酯，其制备方法及其作为药物的用途
- 专利标题： 1.alpha.,7.alpha.-dithio-substituted spirolactones, processes for their preparation, and their use as medicines
- 专利标题（中）： 1α，7α-二硫代取代的己内酯，其制备方法及其作为药物的用途
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申请号： US929292申请日： 1986-10-17
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公开(公告)号： US4789668A公开(公告)日： 1988-12-06
- 发明人: Klaus Nickisch , Henry Laurent , Dieter Bittler , Rudolf Wiechert , Wolfgang Losert
- 申请人： Klaus Nickisch , Henry Laurent , Dieter Bittler , Rudolf Wiechert , Wolfgang Losert
- 申请人地址： DEX Berlin and Bergkamen
- 专利权人： Schering Aktiengesellschaft
- 当前专利权人： Schering Aktiengesellschaft
- 当前专利权人地址： DEX Berlin and Bergkamen
- 优先权： DEX3506100 19850218
- 主分类号： A61K31/585
- IPC分类号： A61K31/585 ; C07J1/00 ; C07J53/00
摘要：
The disclosure relates to novel 1.alpha.,7.alpha.-dithio-substituted spirolactones of general Formula I ##STR1## wherein R.sup.1 is C.sub.1-3 -alkyl and C.sub.1-3 -acyl andR.sup.2 is hydrogen, C.sub.1-3 -alkyl and C.sub.1-3 -acyl,to their preparation, and to their use as medicinal agents.The compounds of this invention exhibit anti-aldosterone activity and show the profile of effectiveness of a pro-drug.