发明授权
US4916149A Diuretic and saluretic 4-chloro-3-sulfamoylbenzoic acid hydrazides
失效
利尿和盐酸4-氯-3-氨磺酰基苯甲酸酰肼
- 专利标题： Diuretic and saluretic 4-chloro-3-sulfamoylbenzoic acid hydrazides
- 专利标题（中）： 利尿和盐酸4-氯-3-氨磺酰基苯甲酸酰肼
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申请号： US295925申请日： 1988-12-29
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公开(公告)号： US4916149A公开(公告)日： 1990-04-10
- 发明人: Endre Palosi , Dezso Korbonits , Erzsebet Molnar nee Bako , Ida Szoboda nee Kanzel , Laszlo Harsing , Gyorgy Simon , Sandor Virag , Vera Gergely , Katalin Marmarosi nee Kellner
- 申请人： Endre Palosi , Dezso Korbonits , Erzsebet Molnar nee Bako , Ida Szoboda nee Kanzel , Laszlo Harsing , Gyorgy Simon , Sandor Virag , Vera Gergely , Katalin Marmarosi nee Kellner
- 申请人地址： HUX Budapest
- 专利权人： Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
- 当前专利权人： Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
- 当前专利权人地址： HUX Budapest
- 优先权： HUX6131/87 19871230
- 主分类号： C07D235/18
- IPC分类号： C07D235/18 ; A61K31/415 ; A61K31/4184 ; A61P3/10 ; A61P7/10 ; C07D235/22 ; C07D235/26 ; C07D235/28
摘要：
The present invention relates to novel compounds of the general formula ##STR1## wherein R is hydrogen atom or a trifluoromethyl, carboxy, C.sub.2-5 alkoxycarbonyl, cyano, benzoyl, sulfamoyl or C.sub.1-4 alkylsulfonyl group;R.sup.1 is hydrogen atom or a linear or branched chain C.sub.1-4 alkyl, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulfonyl, benzylthio, benzylsulfonyl, phenyl, hydroxy or mercapto group; andR.sup.2 is hydrogen or chlorine atom,as well as their pharmaceutically acceptable salts.The compounds according to the invention possess diuretic and saluretic activity with an advantageous Na/K ratio.
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