Invention Grant
- Patent Title: Process for preparing N-sulphonyl-ureas
- Patent Title (中): 制备N-磺酰脲的方法
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Application No.: US317769Application Date: 1989-03-02
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Publication No.: US4954628APublication Date: 1990-09-04
- Inventor: Gabor Besenyei , Sandor Nemeth , Laszlo Simandi , Maria Belak , Maria Szabo , Jozsef Dukai , Lajos Nagy , Elemer Tomordi , Csaba Soptei , Erzsebet E. Dioszegine
- Applicant: Gabor Besenyei , Sandor Nemeth , Laszlo Simandi , Maria Belak , Maria Szabo , Jozsef Dukai , Lajos Nagy , Elemer Tomordi , Csaba Soptei , Erzsebet E. Dioszegine
- Applicant Address: HUX Fufogyartelep HUX Budapest
- Assignee: Nitrokaelepek,Magyar Tudomanyos Akademia Kozponti Kemiai Kutato Intezete
- Current Assignee: Nitrokaelepek,Magyar Tudomanyos Akademia Kozponti Kemiai Kutato Intezete
- Current Assignee Address: HUX Fufogyartelep HUX Budapest
- Priority: HUX2251-1062/88 19880304
- Main IPC: C07D251/16
- IPC: C07D251/16 ; B01J27/13 ; B01J31/16 ; C07B61/00 ; C07C311/60 ; C07D213/75 ; C07D239/42 ; C07D251/18 ; C07D251/22 ; C07D251/46 ; C07D333/34 ; C07D521/00
Abstract:
The invention relates to a process for preparing sulphonyl-ureas of the general formula (I) ##STR1## wherein Ar.sub.1 represents a phenyl, naphthyl or thienyl group, the derivatives thereof substituted by C.sub.1-4 alkyl, C.sub.1-4 haloalkyl, (halo)alkoxycarbonyl, (halo)alkyloxy, nitro, cyano groups as well as by halogen atoms,Ar.sub.2 represents a phenyl, pyridyl, pirimidinyl or triazinyl group and the derivatives thereof substituted by C.sub.1-4 (halo)alkyl, C.sub.1-4 (halo)alkyloxy, amino, O-acyl, O-arylsulphonyl, O-(substituted carbamoyl) groups as well as by halogen atoms.According to the invention N-halogen aryl sulphonamidate is reacted in the presence of a carbonylating catalyst, carbon monoxide and an aromatic amine, optionally in the presence of a phase transfer catalyst, or N-halogen aryl sulphonamidate is reacted with carbon monoxide in the presence of a carbonylating catalyst, and optionally in the presence of a phase transfer catalyst, then the obtained reaction mixture is further reacted with an aromatic amine or an N-halogen-arylamine-alkali metal salt is reacted with aryl-sulphonamid in the presence of a carbonylating catalyst, carbon monoxide and optionally in the presence of a phase transfer catalyst or an amine, amine dihalogenid, aryl sulphonamid are reacted in the presence of a carbonylating catalyst and carbon monoxide and the obtained reaction mixture is worked up in a known manner.The thus prepared sulphonyl-ureas are biologically active compounds, which are used in the pharmaceutical industry and for regulating plant growth.
Public/Granted literature
- US5542290A Control system for chassis dynamometer for simulating road test of automotive vehicle Public/Granted day:1996-08-06
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