公开(公告)号：US5068424A

公开(公告)日：1991-11-26

申请号：US365790

申请日：1989-06-14

申请人： Gabor Besenyei ,  Sandor Nemeth ,  Laszlo Simandi ,  Maria Belak ,  Jozsef Dukai ,  Lajos Nagy ,  Elemer Tomordi ,  Csaba Soptei ,  Erzsebet E. Dioszegine

发明人： Gabor Besenyei ,  Sandor Nemeth ,  Laszlo Simandi ,  Maria Belak ,  Jozsef Dukai ,  Lajos Nagy ,  Elemer Tomordi ,  Csaba Soptei ,  Erzsebet E. Dioszegine

IPC分类号： C07D333/34 ,  A01N47/34 ,  A01N47/40 ,  B01J31/16 ,  C07B61/00 ,  C07C311/53 ,  C07C311/57 ,  C07C311/65

CPC分类号： C07C311/65

摘要： The invention relates to a process for preparing arylsulphonyl isocyanates of the general formula (I) ##STR1## and addition derivatives thereof--where in the formula the meaning of the substituents are as follows:Ar represents optionally substituted aryl, naphthyl- or thienyl group, andHX is a chemical bond or XZR.sub.1 stands for a group where Z is oxygen or sulphur,R.sub.1 is saturated or unsaturated alkyl, benzyl, cyclohexyl or substituted phenyl group orX is an NR.sub.2 R.sub.3 groupwherein R.sub.2 R.sub.3 is hydrogen, alkyl, unsubstituted alkyl, aryl, substituted aryl, aroyl or acyl group, and the essence of the process is that an N-halogen sulphonamidate is carbonylated in the presence of a carbonylating catalyst, in the presence or absence of alcohol, (thio) alcohol or amine reactants and the carbonylated compound obtained is reacted subsequently with the reactants.

摘要翻译： 本发明涉及制备通式（I）的芳基磺酰基异氰酸酯及其加成衍生物的方法，其中在该式中取代基的含义如下：Ar表示任选取代的芳基，萘基或 噻吩基，HX为化学键，X ZR1表示Z为氧或硫的基团，R1为饱和或不饱和的烷基，苄基，环己基或取代的苯基或X为NR2R3基团，其中R2R3为氢，烷基， 未取代的烷基，芳基，取代的芳基，芳酰基或酰基，并且该方法的本质是在羰基化催化剂存在下，在醇，（硫）醇或胺的存在或不存在下羰基化N-卤代磺酰胺 获得的反应物和羰基化的化合物随后与反应物反应。

公开(公告)号：US4954628A

公开(公告)日：1990-09-04

申请号：US317769

申请日：1989-03-02

申请人： Gabor Besenyei ,  Sandor Nemeth ,  Laszlo Simandi ,  Maria Belak ,  Maria Szabo ,  Jozsef Dukai ,  Lajos Nagy ,  Elemer Tomordi ,  Csaba Soptei ,  Erzsebet E. Dioszegine

发明人： Gabor Besenyei ,  Sandor Nemeth ,  Laszlo Simandi ,  Maria Belak ,  Maria Szabo ,  Jozsef Dukai ,  Lajos Nagy ,  Elemer Tomordi ,  Csaba Soptei ,  Erzsebet E. Dioszegine

IPC分类号： C07D251/16 ,  B01J27/13 ,  B01J31/16 ,  C07B61/00 ,  C07C311/60 ,  C07D213/75 ,  C07D239/42 ,  C07D251/18 ,  C07D251/22 ,  C07D251/46 ,  C07D333/34 ,  C07D521/00

CPC分类号： C07D521/00 ,  C07C311/60

摘要： The invention relates to a process for preparing sulphonyl-ureas of the general formula (I) ##STR1## wherein Ar.sub.1 represents a phenyl, naphthyl or thienyl group, the derivatives thereof substituted by C.sub.1-4 alkyl, C.sub.1-4 haloalkyl, (halo)alkoxycarbonyl, (halo)alkyloxy, nitro, cyano groups as well as by halogen atoms,Ar.sub.2 represents a phenyl, pyridyl, pirimidinyl or triazinyl group and the derivatives thereof substituted by C.sub.1-4 (halo)alkyl, C.sub.1-4 (halo)alkyloxy, amino, O-acyl, O-arylsulphonyl, O-(substituted carbamoyl) groups as well as by halogen atoms.According to the invention N-halogen aryl sulphonamidate is reacted in the presence of a carbonylating catalyst, carbon monoxide and an aromatic amine, optionally in the presence of a phase transfer catalyst, or N-halogen aryl sulphonamidate is reacted with carbon monoxide in the presence of a carbonylating catalyst, and optionally in the presence of a phase transfer catalyst, then the obtained reaction mixture is further reacted with an aromatic amine or an N-halogen-arylamine-alkali metal salt is reacted with aryl-sulphonamid in the presence of a carbonylating catalyst, carbon monoxide and optionally in the presence of a phase transfer catalyst or an amine, amine dihalogenid, aryl sulphonamid are reacted in the presence of a carbonylating catalyst and carbon monoxide and the obtained reaction mixture is worked up in a known manner.The thus prepared sulphonyl-ureas are biologically active compounds, which are used in the pharmaceutical industry and for regulating plant growth.

摘要翻译： 本发明涉及一种制备通式（I）的磺酰脲的方法，其中Ar 1表示苯基，萘基或噻吩基，其衍生物被C 1-4烷基，C 1-4卤代烷基， （卤代）烷氧基羰基，（卤代）烷氧基，硝基，氰基以及卤素原子，Ar 2表示苯基，吡啶基，吡啶基或三嗪基，其衍生物被C 1-4（卤代）烷基， 卤代）烷氧基，氨基，O-酰基，O-芳基磺酰基，O-（取代的氨基甲酰基）基团以及卤素原子。 根据本发明，N-卤素芳基磺酰胺酸酯在羰基化催化剂，一氧化碳和芳族胺的存在下，任选地在相转移催化剂存在下反应，或N-卤素芳基磺酰胺盐与一氧化碳在存在下反应 的羰基化催化剂，并且任选地在相转移催化剂存在下，然后将所得反应混合物进一步与芳族胺反应或N-卤素 - 芳基胺 - 碱金属盐在芳基 - 磺酰胺存在下与 羰基化催化剂，一氧化碳和任选在相转移催化剂或胺，胺二卤代芳基磺酰胺存在下，在羰基化催化剂和一氧化碳的存在下反应，并将所得反应混合物以已知方式处理。 如此制备的磺酰脲是生物活性化合物，其用于制药工业和调节植物生长。