发明授权
- 专利标题: Agent for cerebral protection
- 专利标题(中): 脑保护剂
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申请号: US321692申请日: 1989-03-10
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公开(公告)号: US4962107A公开(公告)日: 1990-10-09
- 发明人: Joji Nakamura , Kazuhiro Kubo , Shunji Ichikawa , Hajime Takahashi , Keisuke Isozumi , Toyofumi Yamada
- 申请人: Joji Nakamura , Kazuhiro Kubo , Shunji Ichikawa , Hajime Takahashi , Keisuke Isozumi , Toyofumi Yamada
- 申请人地址: JPX both of JPX both of
- 专利权人: Kyowa Hakko Kogyo Kabushiki Kaisha,Ihara Chemical Kogyo Kabushiki Kaisha
- 当前专利权人: Kyowa Hakko Kogyo Kabushiki Kaisha,Ihara Chemical Kogyo Kabushiki Kaisha
- 当前专利权人地址: JPX both of JPX both of
- 优先权: JPX60-27450 19850214
- 主分类号: A61K31/445
- IPC分类号: A61K31/445 ; A61K31/495 ; A61K31/535 ; A61K31/5375 ; A61K31/54 ; A61P25/28 ; C07D211/16 ; C07D211/22 ; C07D211/46 ; C07D265/30 ; C07D265/32 ; C07D279/12 ; C07D295/18 ; C07D295/185
摘要:
Compounds of the general formula ##STR1## wherein: X is halogen or trifluoromethyl;R.sub.1 is hydrogen, halogen or trifluoromethyl;R.sub.2 is hydrogen methyl or hydroxymethyl;R.sub.3 is hydrogen or lower alkyl; andY is methylene, methylene substituted with a lower alkyl or hydroxyl group, sulfinyl, sulfonyl, oxygen or sulfur, exhibit a cerebral protective effect and are applicable to the treatment of cerebral ischaemia and cerebral hypoxia.The compounds may be made by acylating a suitable piperidine or morpholine with the appropriate cinnamoyl chloride, and if necessary oxidizing the reaction product.
公开/授权文献
- US4406792A Separation agent 公开/授权日:1983-09-27