发明授权
US5001134A Piperidines, processes of preparation and medications containing them
失效
哌啶类,制剂过程和含有它们的药物
- 专利标题: Piperidines, processes of preparation and medications containing them
- 专利标题(中): 哌啶类,制剂过程和含有它们的药物
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申请号: US461515申请日: 1990-01-05
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公开(公告)号: US5001134A公开(公告)日: 1991-03-19
- 发明人: Gerard Ferrand , Herve Dumas , Jean-Claude Depin , Gilles Chavernac
- 申请人: Gerard Ferrand , Herve Dumas , Jean-Claude Depin , Gilles Chavernac
- 申请人地址: FRX Lyons
- 专利权人: Lipha, Lyonnaise Industrielle Pharmaceutique
- 当前专利权人: Lipha, Lyonnaise Industrielle Pharmaceutique
- 当前专利权人地址: FRX Lyons
- 优先权: FRX8900071 19890105
- 主分类号: C07D211/14
- IPC分类号: C07D211/14 ; A61K9/00 ; A61K31/00 ; A61K31/443 ; A61K31/445 ; A61K31/4465 ; A61K31/4523 ; A61K31/4525 ; A61K31/454 ; A61P9/00 ; A61P9/12 ; C07D211/32 ; C07D405/04 ; C07D405/14 ; C07D413/04
摘要:
The present invention relates to piperidines denoted by the formula: ##STR1## in which X is the 4-fluorobenzoyl, 2-(4-fluorophenyl)-1,3-dioxolan-2-yl or 6-fluoro-1,2-benzisoxazol-3-yl group, Y is a hydrogen atom or the hydroxyl group, m is an integer between 0 and 4 inclusive, n is 0 or 1, Q is a nitrogen atom or the methine group; when Q is a nitrogen atom, R is the cyano group or the carbamoyl group; when Q is the methine group, R is the nitro group; R.sup.1 and R.sup.2 may be identical or different and are hydrogen, a lower alkyl radical, the phenyl radical, the 2,2,2-trifluoroethyl group or the 2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl group; or the NR.sup.1 R.sup.2 structural unit is the piperidino radical or the 4-(4-fluorobenzoyl)-1-piperidinyl group.Application of these compounds as antihypertensive medications.
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